Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Regular systems of inbreeding with mutation.

R B Campbell1

  • 1Department of Mathematics and Computer Science, University of Northern Iowa, Cedar Falls 50614-0441.

Theoretical Population Biology
|August 1, 1988
PubMed
Summary

Mutation

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The Psychological Aspect of Physical Education.

Edinburgh medical journal·2018
Same author

THE MANIFESTATION OF PHENOTYPIC SELECTION AT CONSTITUENT LOCI. I. STABILIZING SELECTION.

Evolution; international journal of organic evolution·2017
Same author

Intranasal administration of glial-derived neurotrophic factor (GDNF) rapidly and significantly increases whole-brain GDNF level in rats.

Neuroscience·2015
Same author

The effect of inbreeding constraints and offspring distribution on time to the most recent common ancestor.

Journal of theoretical biology·2015
Same author

Neurotrophic and neuroprotective efficacy of intranasal GDNF in a rat model of Parkinson's disease.

Neuroscience·2014
Same author

Use of perchloric acid as an oxidizing agent.

Science (New York, N.Y.)·2010

Area of Science:

  • Population genetics
  • Quantitative genetics

Background:

  • Inbreeding systems significantly impact genetic diversity and homozygosity within populations.
  • Understanding the effects of mutation is crucial for accurate population genetic models.

Purpose of the Study:

  • To analyze the probability of identity by type in regular inbreeding systems with mutation.
  • To compare different inbreeding scenarios (half-sib, first cousin, half nth cousin) under various mutation models.

Main Methods:

  • Analytical derivations for probability of identity by type.
  • Modeling using infinite allele and two-allele (back mutation) models.
  • Comparison of results across different mating systems and mutation rates.

Main Results:

  • Mutation rates at reasonable levels do not substantially alter results compared to models without mutation.
  • Half-sib mating leads to higher homozygosity than first cousin mating.
  • First cousin mating results in a higher expected number of gene copies than half-sib mating.

Conclusions:

  • Inbreeding systems and mutation interact to influence genetic identity and homozygosity.
  • The choice of inbreeding system has distinct consequences for gene diversity and copy number.
  • Mutation's impact on identity by type is less pronounced than previously assumed at typical rates.

Related Experiment Videos