Estimating a normal reference range for serum B-cell maturation antigen levels for multiple myeloma patients

Area of Science:

• Hematology
• Clinical Chemistry
• Oncology

Background:

• Serum B-cell maturation antigen (sBCMA) is a novel biomarker for multiple myeloma.
• Establishing a reference range for sBCMA is crucial for its clinical application.
• Previous studies have not defined normal sBCMA levels.

Purpose of the Study:

• To determine the reference range for serum B-cell maturation antigen (sBCMA) in healthy individuals.
• To provide a benchmark for interpreting sBCMA levels in multiple myeloma patients.

Main Methods:

• Serum samples from 196 healthy subjects were analyzed for sBCMA levels.
• Statistical analysis, including non-parametric methods, was used to establish the reference interval.
• The distribution of sBCMA levels was assessed.

Main Results:

• sBCMA levels in healthy subjects exhibited a right-tailed distribution.
• The median sBCMA level was 37.51 ng/ml, with a standard deviation of 22.54 ng/ml.
• A universal reference interval of <82.59 ng/ml was suggested based on median ± 2 standard deviations.

Conclusions:

• A reference interval for sBCMA in healthy individuals has been established.
• The suggested reference range of <82.59 ng/ml can aid in the interpretation of sBCMA levels in multiple myeloma.
• This study provides essential data for the clinical utility of sBCMA as a biomarker.