Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Factors Affecting Renal Clearance: Renal Impairment01:17

Factors Affecting Renal Clearance: Renal Impairment

349
Renal dysfunction significantly impairs the renal clearance of drugs, leading to potential complications in drug therapy. Renal failure, which can be caused by various factors, poses a significant challenge in the elimination of drugs from the body.
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
349
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion01:18

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion

185
In geriatric patients, renal physiology undergoes significant changes, including diminished renal blood flow and a lower glomerular filtration rate (GFR), leading to alterations in medication clearance. Drugs such as aminoglycoside antibiotics, lithium, and digoxin, which rely on glomerular filtration for removal from the body, particularly impact pharmacokinetics. These drugs tend to have slower clearance rates in older adults, necessitating careful dosage considerations.Evaluation of renal...
185
Acute Kidney Injury IV: Diagnostic Studies and Prevention01:30

Acute Kidney Injury IV: Diagnostic Studies and Prevention

210
Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
210
Chronic Kidney Disease I: Introduction01:25

Chronic Kidney Disease I: Introduction

477
Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage renal disease. At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate for...
477
Drug Dosing in Renal Diseases: Estimation of Glomerular Filtration Rate Based on Serum Creatinine Concentration01:28

Drug Dosing in Renal Diseases: Estimation of Glomerular Filtration Rate Based on Serum Creatinine Concentration

116
Glomerular filtration rate (GFR) can be estimated from serum creatinine using the modification of diet in renal disease (MDRD) formula or the chronic kidney disease–epidemiology collaboration (CKD–EPI) equation. Both methods are widely used in clinical practice to assess kidney function and guide treatment decisions.The MDRD equation does not require weight or height measurements and is normalized to the body surface area of 1.73 m², considered the average adult surface area.
116
Renal Failure: Dose Adjustments01:11

Renal Failure: Dose Adjustments

355
In patients with renal impairment, drugs undergo significant changes in their pharmacokinetics, which require dosage adjustments to ensure safe and effective therapy.
Reduced renal clearance and elimination rate are common outcomes of renal impairment. These alterations lead to a prolonged elimination half-life and an altered apparent volume of distribution for drugs. As a result, dosage adjustments are typically necessary to maintain optimal drug levels in the body.
However, dosage adjustments...
355

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Influence of food groups on plasma total homocysteine for specific MTHFR C677T genotypes in Chinese population.

Molecular nutrition & food research·2016
Same author

NIR Light Propulsive Janus-like Nanohybrids for Enhanced Photothermal Tumor Therapy.

Small (Weinheim an der Bergstrasse, Germany)·2016
Same author

Smart Hydrogels with Inhomogeneous Structures Assembled Using Nanoclay-Cross-Linked Hydrogel Subunits as Building Blocks.

ACS applied materials & interfaces·2016
Same author

Synergy between von Hippel-Lindau and P53 contributes to chemosensitivity of clear cell renal cell carcinoma.

Molecular medicine reports·2016
Same author

Aerobic Degradation of Sulfadiazine by Arthrobacter spp.: Kinetics, Pathways, and Genomic Characterization.

Environmental science & technology·2016
Same author

Downregulation of ClC-3 in dorsal root ganglia neurons contributes to mechanical hypersensitivity following peripheral nerve injury.

Neuropharmacology·2016

Related Experiment Video

Updated: Dec 23, 2025

Cryosectioning and Immunostaining Mouse Inner Ear Tissue: From Embryonic to Adult Stages
09:09

Cryosectioning and Immunostaining Mouse Inner Ear Tissue: From Embryonic to Adult Stages

Published on: April 11, 2025

1.5K

The association between reduced kidney function and hearing loss: a cross-sectional study.

Wenwen Liu1, Qinqin Meng2, Yafeng Wang2

  • 1Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, China.

BMC Nephrology
|April 24, 2020
PubMed
Summary

Reduced kidney function is linked to a higher risk of hearing loss in middle-aged and older Chinese adults. This study highlights the importance of monitoring hearing in individuals with chronic kidney disease.

Keywords:
CHARLSHearing lossMultivariable logistic regressionReduced kidney functioneGFR

More Related Videos

Modified Experimental Conditions for Noise-Induced Hearing Loss in Mice and Assessment of Hearing Function and Outer Hair Cell Damage
07:13

Modified Experimental Conditions for Noise-Induced Hearing Loss in Mice and Assessment of Hearing Function and Outer Hair Cell Damage

Published on: February 10, 2023

2.7K
Assessment of Kidney Function in Mouse Models of Glomerular Disease
09:16

Assessment of Kidney Function in Mouse Models of Glomerular Disease

Published on: June 30, 2018

18.4K

Related Experiment Videos

Last Updated: Dec 23, 2025

Cryosectioning and Immunostaining Mouse Inner Ear Tissue: From Embryonic to Adult Stages
09:09

Cryosectioning and Immunostaining Mouse Inner Ear Tissue: From Embryonic to Adult Stages

Published on: April 11, 2025

1.5K
Modified Experimental Conditions for Noise-Induced Hearing Loss in Mice and Assessment of Hearing Function and Outer Hair Cell Damage
07:13

Modified Experimental Conditions for Noise-Induced Hearing Loss in Mice and Assessment of Hearing Function and Outer Hair Cell Damage

Published on: February 10, 2023

2.7K
Assessment of Kidney Function in Mouse Models of Glomerular Disease
09:16

Assessment of Kidney Function in Mouse Models of Glomerular Disease

Published on: June 30, 2018

18.4K

Area of Science:

  • Nephrology
  • Audiology
  • Epidemiology

Background:

  • The association between kidney function and hearing loss is established but often based on limited data.
  • Previous evidence primarily stems from small observational studies or specific populations.

Purpose of the Study:

  • To investigate the relationship between diminished kidney function and hearing loss.
  • To analyze this association in a large, population-based cohort of middle-aged and elderly Chinese individuals.

Main Methods:

  • Utilized data from 12,508 participants aged 45+ in the 2015 Chinese Health and Retirement Longitudinal Study (CHARLS).
  • Assessed kidney function using estimated glomerular filtration rate (eGFR) and defined hearing loss based on self-reported survey responses.
  • Employed multivariable logistic regression to adjust for demographic, behavioral, and cardiovascular risk factors.

Main Results:

  • The prevalence of self-reported hearing loss was 23.6% in the study cohort.
  • Participants with lower eGFR levels (60-89 and <60 mL/min/1.73 m²) exhibited a significantly increased risk of hearing loss compared to those with eGFR ≥90 mL/min/1.73 m².
  • Adjusted odds ratios for hearing loss were 1.11 (95% CI: 1.00-1.23) for eGFR 60-89 and 1.25 (95% CI: 1.04-1.49) for eGFR <60.

Conclusions:

  • Reduced kidney function is independently associated with an increased risk of hearing loss.
  • Routine hearing assessments should be integrated into the care of patients diagnosed with chronic kidney disease.