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Updated: Dec 23, 2025

Evidence-based Knowledge Synthesis and Hypothesis Validation: Navigating Biomedical Knowledge Bases via Explainable AI and Agentic Systems
Published on: June 13, 2025
The evidence landscape in precision medicine
Spencer Phillips Hey1,2, Cory V Gerlach3,4,5, Garrett Dunlap3,6
1Harvard Center for Bioethics, Harvard Medical School, Boston, MA, USA. spencer_hey@hms.harvard.edu.
Abstract:
Precision medicine is beginning to make an impact on the treatment of different diseases, but there are still challenges that must be overcome, such as the complexity of interventions, the need for marker validation, and the level of evidence necessary to demonstrate effectiveness. In this Perspective, we describe how evidence landscapes can help to address these challenges.
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