Related Experiment Video
Updated: Dec 23, 2025
06:23
Applying Advanced In Vitro Culturing Technology to Study the Human Gut Microbiota
Published on: February 15, 2019
14.7K
Mycobiome in the Gut: A Multiperspective Review
Voon Kin Chin1, Voon Chen Yong1, Pei Pei Chong1
1School of Biosciences, Faculty of Health and Medical Sciences, Taylor's University Lakeside Campus, 47500 Subang Jaya, Malaysia.
Mediators of Inflammation
|April 24, 2020
Summary
The human gut harbors a complex fungal community, the mycobiome, influencing health and disease. Research is exploring its role in immunity, the gut-brain axis, and interactions with bacteria and diet.
Area of Science:
- Microbiology
- Gastroenterology
- Immunology
Background:
- The human gut hosts a complex ecosystem of microorganisms, including fungi, known as the mycobiome.
- While the gut microbiota's role in health and disease is studied, the mycobiome's specific functions are less understood.
- Advances in sequencing and computational biology enable detailed analysis of gut fungal communities.
Purpose of the Study:
- To review recent advances in gut mycobiome research from multiple perspectives.
- To discuss the composition of gut fungal communities and their involvement in host immunity and the gut-brain axis.
- To highlight the influence of diet, multibiome interactions (especially fungi-bacteria), and fungal metabolites on the gut mycobiome and host health.
Main Methods:
- Literature review of recent studies on gut mycobiome.
- Analysis of fungal community composition using sequencing technologies.
- Exploration of host-microbe interactions and metabolic pathways.
Main Results:
- The gut mycobiome plays a role in host homeostasis and disease development.
- Fungi-bacteria interactions and dietary factors significantly shape mycobiome composition.
- Fungal metabolites are implicated in host health and disease states.
Conclusions:
- The gut mycobiome is an emerging area of research with significant implications for human health.
- Further investigation into the mechanisms of mycobiome involvement in immunity, the gut-brain axis, and disease is warranted.
- Understanding the gut mycobiome offers potential for novel therapeutic strategies.
Related Concept Videos
01:29Bacterial Flora of the Large Intestine
1.4K
The gut microbiome is formed by a vast and diverse community of bacteria that colonizes our large intestine. These bacteria start residing in the gut from birth and continue diversifying throughout life, influenced by factors such as diet, lifestyle, and stress. The gut bacterial community also includes bacteria from food and those that enter the colon through the anus.
The normal gut flora of the colon plays a critical role in generating essential vitamins such as vitamins K, B5, and B7.
The normal gut flora of the colon plays a critical role in generating essential vitamins such as vitamins K, B5, and B7.
1.4K
01:29Microorganisms in Medicine and Therapeutics
836
Microorganisms play a fundamental role in vaccine development, gene therapy, and therapeutic production. Their biological properties are harnessed to advance medicine and public health. Beyond immunization, microorganisms contribute to gut health, antibiotic synthesis, and genetic disease treatment.Live Attenuated and Inactivated VaccinesLive attenuated vaccines, such as the measles, mumps, and rubella (MMR) vaccine, utilize weakened forms of pathogens to closely resemble natural infections.
836
02:11The Roles of Bacteria and Fungi in Plant Nutrition
46.4K
Plants have the impressive ability to create their own food through photosynthesis. However, plants often require assistance from organisms in the soil to acquire the nutrients they need to function correctly. Both bacteria and fungi have evolved symbiotic relationships with plants that help the species to thrive in a wide variety of environments.
46.4K
01:17Chronic Bowel Disorders: Introduction
696
Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
696
01:05Physiology of Enteric Nervous System and Gut Health
777
The gastrointestinal tract, responsible for the digestion and absorption of nutrients, is safeguarded by the intestinal barrier, which consists of secretory, physical, and immune components. At the forefront is the secretory barrier, composed of essential elements such as mucus, gut microbiota, and defense proteins. They collaborate to break down food particles, facilitate nutrient absorption, and maintain optimal gut health. These secretory components ensure the smooth functioning of the...
777
01:23Anatomy of the Intestines
86.3K
Although digestion of proteins, carbohydrates, and lipids may begin in the stomach, it is completed in the intestine. The absorption of nutrients, water, and electrolytes from food and drink also occurs in the intestine. The intestines can be divided into two structurally distinct organs—the small and large intestines.
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...
86.3K