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Updated: Dec 23, 2025

Modeling Primary Bone Tumors and Bone Metastasis with Solid Tumor Graft Implantation into Bone
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Cerebral metastasis from osteosarcoma: "Bone" in the brain.

Stefania Kokkali1, Efthymios Andriotis2, Elena Katsarou1

  • 1First Medical Oncology Clinic, Saint-Savvas Cancer Hospital, L. Alexandras 171, 11522 Athens, Greece.

Radiology Case Reports
|April 24, 2020
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Summary

Brain metastases from osteosarcoma are rare but increasing. This case study details a young male treated successfully with cabozantinib for cerebellar metastasis, highlighting new therapeutic avenues.

Keywords:
Brain metastasisCalcificationOsteosarcoma

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Area of Science:

  • Oncology
  • Neurology
  • Radiology

Background:

  • Brain metastases from bone and soft tissue sarcoma are uncommon but rising due to improved sarcoma treatments.
  • Osteosarcoma, a primary bone cancer, rarely metastasizes to the brain.

Observation:

  • A 23-year-old male with metastatic femoral osteosarcoma presented with headache and ataxia.
  • Cerebellar metastasis was diagnosed via CT scan, showing a calcified mass with edema.
  • Neurological symptoms resolved with corticosteroid treatment.

Findings:

  • The patient received systemic therapy with cabozantinib for lung and cerebellar metastases.
  • Radiation therapy was omitted due to the radioresistance of osteosarcoma.

Implications:

  • This case highlights the potential of systemic tyrosine kinase inhibitors like cabozantinib in managing rare brain metastases from osteosarcoma.
  • Effective management of neurological symptoms with corticosteroids is crucial.
  • Further research into targeted therapies for CNS metastases in sarcoma is warranted.