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Updated: Dec 23, 2025

Developing a Rat Model for Bipolar Disorder

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Published on: May 2, 2025

Rodent models for psychiatric disorders: problems and promises.

Matthew Baker¹, Sa-Ik Hong¹, Seungwoo Kang¹

¹1Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905 USA.

Laboratory Animal Research

|April 24, 2020

Summary

Genetically modified rodent models are crucial for understanding psychiatric disorders, but advanced techniques are needed to overcome challenges in drug development for these complex brain conditions.

Keywords:

Behaviors Circuits Genetics Psychiatric disorders Rodent models

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Rodent Brain Microinjection to Study Molecular Substrates of Motivated Behavior

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Published on: September 16, 2015

Area of Science:

Neuroscience
Genetics
Psychiatry

Background:

Psychiatric disorders affect over 900 million people globally, incurring significant societal costs.
Genetically modified rodent models have been instrumental in studying the genetic and molecular underpinnings of these conditions since the 1980s.
Despite progress, challenges persist in translating findings from rodent models to effective human treatments, partly due to the polygenetic nature of mental disorders.

Purpose of the Study:

To review the current challenges and future promises of using rodent models in psychiatric disorder research.
To highlight advanced techniques and their applications in developing more effective treatments for mental and substance use disorders.
To emphasize the need for cell type-specific analyses in rodent models to unravel brain complexity.

Main Methods:

Review of existing literature on rodent models in psychiatric research.
Focus on advanced techniques applicable to genetically modified rodents.
Discussion of applications in understanding gene-environment interactions and neural circuits.

Main Results:

Rodent models offer valuable insights into the genetic and molecular basis of psychiatric disorders.
Advanced techniques enable more precise investigations into cell type-specific gene functions and neural circuits.
Human genetics reveal the polygenetic nature of mental disorders, necessitating sophisticated models.

Conclusions:

Rodent models remain essential tools for psychiatric disorder research and drug development.
Advanced techniques are critical for overcoming limitations and improving the translational relevance of rodent models.
Cell type-specific approaches in rodent models are key to advancing our understanding and treatment of complex brain disorders.