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Related Experiment Video

Updated: Dec 23, 2025

Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing

Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing

Published on: October 15, 2019

Gut Microbiota and Multiple Organ Dysfunction Syndrome (MODS).

Peng Chen¹, Timothy Billiar²

¹Department of Pathophysiology, Guangdong Provincial Key Laboratory of Proteomics, School of Basic Medical Sciences, Southern Medical University, N.No.1838 Guangzhou Ave., Guangzhou, 510515, China.

Advances in Experimental Medicine and Biology

|April 24, 2020

Summary

Multiple organ dysfunction syndrome (MODS) involves organ failure during infection. Gut microbiota alterations impact MODS progression, suggesting it as a potential therapeutic target for sepsis management.

Keywords:

Gut microbiota MODS Sepsis

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Published on: May 2, 2018

Area of Science:

Microbiology
Immunology
Critical Care Medicine

Background:

Multiple organ dysfunction syndrome (MODS) is a critical condition involving failure of two or more organs, often triggered by infection, shock, or trauma.
Sepsis, defined as infection with MODS, involves complex systemic inflammation and cellular stress responses.
The gut microbiota's role in MODS and sepsis pathogenesis is significant but not fully understood, with emerging evidence of its dual impact.

Purpose of the Study:

To summarize current research on the functional relationship between gut microbiota and sepsis.
To highlight how enteric microbial composition and function are altered during sepsis.
To propose the gut microbiota as a potential therapeutic target for sepsis management.

Main Methods:

Review of recent studies investigating the gut microbiota in the context of sepsis.
Analysis of research on microbial products' influence on sepsis progression.
Synthesis of evidence linking gut microbial alterations to organ dysfunction in sepsis.

Main Results:

Gut microbial composition and function are demonstrably disrupted during sepsis.
Microbial products from the gut can either exacerbate or mitigate sepsis progression.
The gut microbiota plays a crucial role in the pathobiology of sepsis and organ dysfunction.

Conclusions:

The gut microbiota is intricately linked to the development and progression of sepsis.
Modulating the gut microbiota may offer a novel therapeutic strategy for managing sepsis.
Further research into the gut microbiota's functional role in sepsis is warranted for clinical application.