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Anterior Cingulate Cortex Implants for Alcohol Addiction: A Feasibility Study.

Sook Ling Leong1,2, Paul Glue3, Patrick Manning4

  • 1Trinity College Institute of Neuroscience, Trinity College Dublin, Dublin, Ireland. sookling.leong@tcd.ie.

Neurotherapeutics : the Journal of the American Society for Experimental Neurotherapeutics
|April 24, 2020
PubMed
Summary
This summary is machine-generated.

This study explored using brain implants to reduce alcohol cravings in severe alcohol dependence. Electrode stimulation of the rostrodorsal anterior cingulate cortex (rdACC) significantly decreased craving, suggesting a potential new treatment.

Keywords:
Alcohol cravingAlcohol dependenceAnterior cingulate cortexCortical stimulation

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Area of Science:

  • Neuroscience
  • Neuromodulation
  • Addiction Research

Background:

  • Intense alcohol craving is linked to abnormal neural activity in the rostrodorsal anterior cingulate cortex (rdACC).
  • Neuromodulation via cortical implants offers a potential avenue for treating alcohol dependence resistant to conventional therapies.

Purpose of the Study:

  • To evaluate the effectiveness and feasibility of using cortical implants to suppress alcohol craving.
  • To investigate the impact of rdACC neuromodulation on alcohol craving in individuals with severe alcohol use disorder.

Main Methods:

  • A controlled one-group pre- and post-test study was conducted.
  • Eight participants with intractable alcohol dependence received bilateral rdACC implants with electrodes connected to an internal pulse generator.
  • Self-reported alcohol craving and electrophysiological data were primary endpoints.

Main Results:

  • A significant 60.7% reduction in self-reported alcohol craving was observed post-stimulation compared to pre-stimulation (p=0.004).
  • Electrophysiology revealed a decrease in rdACC beta 1 band current density among responders (p=0.026).
  • Adverse events were reported in four of the eight participants.

Conclusions:

  • rdACC stimulation via implanted electrodes shows potential feasibility for suppressing alcohol craving in severe alcohol use disorder.
  • Further research through larger, controlled clinical trials is necessary to confirm the safety and efficacy of this neuromodulation technique.