Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Diversity of Antigen Receptors01:28

Diversity of Antigen Receptors

1.3K
Antigen receptors are essential components of the immune system crucial in defending the body against foreign invaders. These receptors are present on the surface of B and T cells, enabling them to recognize antigens and mount an appropriate immune response.
Before encountering any antigen, lymphocytes express these receptors. On B cells, the antigen receptor is a membrane-bound antibody molecule called BCR; on T cells, it is a T cell receptor or TCR. B and T cell receptors are composed of two...
1.3K
B Cell Activation and Differentiation01:24

B Cell Activation and Differentiation

15.6K
The adaptive immune response, a sophisticated defense mechanism, relies on the activation and differentiation of B lymphocytes, or B cells. These processes enable our bodies to mount a tailored response against specific pathogens such as bacteria, free virus particles, toxins, and parasites.
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
15.6K
Receptor Downregulation in MVBs01:15

Receptor Downregulation in MVBs

2.7K
Multivesicular bodies (MVBs) are mature endosomes that sort ubiquitinated proteins and then fuse with lysosomes to degrade the sorted proteins. Epidermal growth factor (EGF) and its receptor (EGFR) form a complex that can be internalized through endocytosis, sorted into an MVB, and later degraded.
The EGFR can initiate signaling pathways that  lead to cell proliferation, migration, and differentiation. Overexpression of EGFR  stimulates cells to proliferate. Excessive  EGFR...
2.7K
Cell Signaling in Plants01:25

Cell Signaling in Plants

6.1K
Plant cells communicate to coordinate their cycle of growth, flowering and fruiting, and activities in roots, shoots, and leaves in response to the changing environmental conditions. Plant signaling is distinct from animal signaling. Plants primarily utilize enzyme-linked receptors, whereas the largest class of cell-surface receptors in animals are G-protein coupled receptors (GPCRs). Unlike animals, receptor tyrosine kinases are rare in plants. Instead, plants have a diverse class of...
6.1K
Overview of Cell Signaling01:23

Overview of Cell Signaling

23.6K
Despite the protective membrane that separates a cell from the environment, cells need the ability to detect and respond to environmental changes. Additionally, cells often need to communicate with one another. Unicellular and multicellular organisms use a variety of cell signaling mechanisms to communicate with the environment.
Cells respond to many types of information, often through receptor proteins positioned on the membrane. For example, skin cells respond to and transmit touch...
23.6K
What is Cell Signaling?02:03

What is Cell Signaling?

129.1K
Despite the protective membrane that separates a cell from the environment, cells need the ability to detect and respond to environmental changes. Additionally, cells often need to communicate with one another. Unicellular and multicellular organisms use a variety of cell signaling mechanisms to communicate to respond to the environment.
129.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Discovery of Novel RASGRF2 Fusions as a Therapeutic Target in Lung Adenocarcinoma of Never or Light Smokers.

Cancer science·2025
Same author

Reply: Reflections on Early Rehabilitation in Acute Heart Failure.

JACC. Heart failure·2025
Same author

Impact of Early Ambulation on Recovery Following Open Abdominal Aortic Aneurysm Repair.

Annals of vascular surgery·2025
Same author

Utility of a Novel High-Sensitivity Multiplex Companion Diagnostic Test Using Formalin-Fixed Paraffin-Embedded Cell Block Materials of Non-small Cell Lung Cancer.

Cancer medicine·2025
Same author

Prognostic value of symptom burden as a simple patient-reported outcome measure in older patients with heart failure.

Scientific reports·2025
Same author

A non-spike nucleocapsid R204P mutation in SARS-CoV-2 Omicron XEC enhances inflammation and pathogenicity.

bioRxiv : the preprint server for biology·2025

Related Experiment Video

Updated: Dec 23, 2025

A BW Reporter System for Studying Receptor-Ligand Interactions
06:05

A BW Reporter System for Studying Receptor-Ligand Interactions

Published on: January 7, 2019

8.0K

B Cell Receptor Signaling.

Shinya Tanaka1, Yoshihiro Baba2

  • 1Division of Immunology and Genome Biology, Department of Molecular Genetics, Medical Institute of Bioregulation, Kyushu University, Higashi-Ku, Fukuoka, 812-8582, Japan. stanaka@bioreg.kyushu-u.ac.jp.

Advances in Experimental Medicine and Biology
|April 24, 2020
PubMed
Summary

B cell receptor (BCR) signaling is crucial for B cell development, immunity, and preventing autoimmunity. This review covers how BCR signaling activation and repression are controlled to ensure proper immune responses.

Keywords:
B cell receptorCalcium signalMAPKNF-kBPI3KSHIPSHP

More Related Videos

A TIRF Microscopy Technique for Real-time, Simultaneous Imaging of the TCR and its Associated Signaling Proteins
16:10

A TIRF Microscopy Technique for Real-time, Simultaneous Imaging of the TCR and its Associated Signaling Proteins

Published on: March 22, 2012

24.3K
Studying Organelle Dynamics in B Cells During Immune Synapse Formation
15:39

Studying Organelle Dynamics in B Cells During Immune Synapse Formation

Published on: June 1, 2019

9.5K

Related Experiment Videos

Last Updated: Dec 23, 2025

A BW Reporter System for Studying Receptor-Ligand Interactions
06:05

A BW Reporter System for Studying Receptor-Ligand Interactions

Published on: January 7, 2019

8.0K
A TIRF Microscopy Technique for Real-time, Simultaneous Imaging of the TCR and its Associated Signaling Proteins
16:10

A TIRF Microscopy Technique for Real-time, Simultaneous Imaging of the TCR and its Associated Signaling Proteins

Published on: March 22, 2012

24.3K
Studying Organelle Dynamics in B Cells During Immune Synapse Formation
15:39

Studying Organelle Dynamics in B Cells During Immune Synapse Formation

Published on: June 1, 2019

9.5K

Area of Science:

  • Immunology
  • Cell Biology
  • Molecular Biology

Background:

  • B cell receptor (BCR) signaling is vital for B cell development, immune responses, and maintaining self-tolerance.
  • Dysregulated BCR signaling can lead to autoimmunity.
  • BCR signaling controls B cell progression from early development to effector functions.

Purpose of the Study:

  • To review the mechanisms controlling B cell receptor (BCR) signaling.
  • To highlight the roles of positive and negative regulators in BCR signaling pathways.
  • To discuss recent findings on BCR signaling activation and repression.

Main Methods:

  • Literature review of recent findings on BCR signaling.
  • Analysis of intracellular positive and negative regulators of BCR signaling.
  • Examination of BCR's role in B cell development, autoimmunity, and immune responses.

Main Results:

  • BCR signaling acts as a gatekeeper in B cell development and a key player in eliminating autoreactive B cells.
  • Antigen recognition by BCR is essential for T cell help and differentiation into plasma, germinal center, and memory B cells.
  • BCR signaling tightly regulates B cell activation to prevent autoimmunity.

Conclusions:

  • BCR signaling is essential for effective immune responses and is tightly regulated by intracellular mechanisms.
  • Understanding BCR signaling control is critical for managing autoimmune diseases and enhancing host defense.
  • Recent research provides insights into the complex activation and repression of BCR signaling.