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Updated: Dec 23, 2025
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In Vitro Differentiation Model of Human Normal Memory B Cells to Long-lived Plasma Cells
Published on: January 20, 2019
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Regulation of Plasma Cell Differentiation
W Ise1, T Kurosaki2,3
1Laboratory of Lymphocyte Differentiation, WPI Immunology Frontier Research Center, Osaka University, Osaka, 565-0871, Japan. wise@ifrec.osaka-u.ac.jp.
Advances in Experimental Medicine and Biology
|April 24, 2020
Summary
Long-lived plasma cells, crucial for long-term immunity, develop from germinal center (GC) B cells. This review explores the cellular and molecular mechanisms driving plasma cell differentiation from GC B cells.
Area of Science:
- Immunology
- Cell Biology
Background:
- Humoral immunity relies on antibodies produced by plasma cells.
- Plasma cells differentiate from activated B cells and are key antibody secretors.
- Long-lived plasma cells, essential for sustained protection, primarily originate from germinal center (GC) responses.
Purpose of the Study:
- To review recent advancements in understanding plasma cell differentiation.
- To elucidate the cellular and molecular underpinnings of plasma cell development from GC B cells.
Main Methods:
- Literature review of recent scientific progress.
- Analysis of cellular and molecular mechanisms involved in B cell differentiation.
Main Results:
- Germinal center B cells are major precursors for long-lived plasma cells.
- Specific cellular and molecular pathways govern plasma cell differentiation from GC B cells.
Conclusions:
- Understanding plasma cell differentiation from GC B cells is critical for long-term humoral immunity.
- Further research into these pathways can inform strategies for enhancing protective immunity.
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