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[Renin-Angiotensin-System (RAS) and COVID-19 - On The Prescription of RAS Blockers].
Deutsche Medizinische Wochenschrift (1946)
|April 24, 2020
Summary
Angiotensin-converting enzyme 2 (ACE2) is crucial for SARS-CoV-2 entry. Despite concerns, renin-angiotensin system blockers are recommended for stable COVID-19 patients.
Area of Science:
- Cardiovascular Medicine
- Virology
- Biochemistry
Background:
- Angiotensin-converting enzyme 2 (ACE2) plays a counter-regulatory role in the renin-angiotensin system (RAS), influencing blood pressure and cardiovascular remodeling.
- ACE2 serves as the cellular receptor for SARS-CoV and SARS-CoV-2, linking cardiovascular medicine and virology.
- Concerns arose that RAS blockers might exacerbate COVID-19 by upregulating ACE2 expression.
Purpose of the Study:
- To elucidate the intricate relationship between the RAS, specifically ACE2, and COVID-19.
- To evaluate the impact of RAS-modulating therapies in the context of the pandemic.
Main Methods:
- Review and analysis of existing scientific literature and findings.
- Evaluation of the role of ACE2 in viral entry and its interaction with RAS inhibitors.
Main Results:
- ACE2 is the primary binding receptor for SARS-CoV-2.
- The study critically assessed the hypothesis linking RAS blockers to increased COVID-19 severity.
Conclusions:
- Available evidence does not support discontinuing RAS inhibitors in stable patients.
- Continuation of ACE inhibitors and angiotensin receptor blockers according to guidelines is justified for stable patients during the COVID-19 pandemic.
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