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Mechanism-based treatment of cancer with immune checkpoint inhibitor therapies

Yara Abdou1, Manu Pandey1, Maithreyi Sarma1

  • 1Department of Medicine, Roswell Park Comprehensive Cancer Center, Buffalo, New York.

British Journal of Clinical Pharmacology
|April 24, 2020
PubMed

Immune checkpoints are cell surface molecules that initiate regulatory pathways which have powerful control of CD8+ cytolytic T cell activity. Antagonistic and agonistic antibodies engaging these molecules have demonstrated profound impact on immune activation and have entered clinical use for the treatment of a variety of diseases. Over the past decade, antagonistic antibodies known as immune checkpoint inhibitors have become a new pillar of cancer treatment and have reshaped the therapeutic landscape in oncology. These agents differ in their mechanism of action and toxicity profiles compared to more traditional systemic cancer treatments such as chemo- and targeted therapies. This article reviews the pharmacology of this new class of agents.

Keywords:
CTLA-4PD-1PD-L1checkpoint inhibitorimmune checkpointsimmunotherapyresistance

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