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The association between cardiac autonomic neuropathy and heart function in type 2 diabetic patients

Kyung Ae Lee1, Yu Ji Kim1, Tae Sun Park1

  • 1Division of Endocrinology and Metabolism, Department of Internal Medicine, Research Institute of Clinical Medicine of Jeonbuk National University, Biomedical Research Institute of Jeonbuk National University Hospital, Jeonbuk National University Medical School, Jeonju, South Korea.

Somatosensory & Motor Research
|April 24, 2020
PubMed

Insights

Diabetic patients with cardiac autonomic neuropathy (CAN) show higher rates of diastolic dysfunction. While CAN is common in diabetes, its direct link to heart function requires further investigation.

Area of Science:

  • Cardiology
  • Diabetology
  • Neurology

Background:

  • Cardiac autonomic neuropathy (CAN) is a significant complication of diabetes.
  • Diabetic cardiomyopathy leading to heart failure is a critical concern.
  • The precise relationship between CAN and heart function in diabetes remains under-researched.

Purpose of the Study:

  • To investigate the association between cardiac autonomic neuropathy (CAN) parameters and heart function in type 2 diabetic patients.
  • To determine if CAN is linked to specific indicators of cardiac dysfunction, such as diastolic dysfunction.

Main Methods:

  • Retrospective review of 100 type 2 diabetic patients' medical records from January 2018 to December 2018.
  • Analysis of autonomic function tests (heart rate variability - HRV) and echocardiography data.
  • Statistical analysis to assess the correlation between CAN parameters and cardiac function indicators.

Main Results:

  • 65 out of 100 patients were diagnosed with CAN; 26 showed diastolic dysfunction.
  • Diastolic dysfunction was more prevalent in diabetic patients with CAN (73.1%) compared to those without CAN (20.0%).
  • No significant associations were found between HRV parameters and heart function.

Conclusions:

  • Diastolic dysfunction is more common in diabetic patients with CAN.
  • The study highlights a higher prevalence of CAN in patients with diastolic dysfunction.
  • Further longitudinal studies are needed to confirm the exact association between CAN progression and heart function in diabetic patients.

Keywords:
Cardiac autonomic neuropathydiabetesdiastolic dysfunctionheart function

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