Fixed-point "blasting" triggered by second near-infrared window light for augmented interventional photothermal...

Area of Science:

• Biomedical Engineering
• Nanotechnology
• Oncology

Background:

• Current cancer therapies face limitations in efficacy and invasiveness.
• Developing minimally invasive and highly effective tumor destruction methods is crucial.

Purpose of the Study:

• To develop a fixed-point "blasting" strategy for interventional photothermal therapy.
• To create an injectable, in situ-forming hydrogel system for targeted tumor destruction.

Main Methods:

• Composed "blasting" materials of photothermal nanoparticles (ancient ink nanoparticles, AINP) and a phase change agent (perfluoromethylcyclopentane, FMCP).
• Utilized a thermal-responsive hydrogel carrier for AINP and FMCP, which solidifies at body temperature.
• Administered the hydrogel as an injectable solution that forms a gel in situ, localizing therapeutic agents within the tumor.

Main Results:

• The hydrogel system successfully localized AINP and FMCP within the tumor site.
• Second window near-infrared light triggered photothermal effects and gas mechanical damage, leading to effective tumor destruction.
• Demonstrated a proof-of-concept for fixed-point "blasting" in interventional photothermal therapy.

Conclusions:

• The developed fixed-point "blasting" strategy offers a promising new approach for cancer interventional photothermal therapy.
• The injectable, in situ-forming hydrogel system effectively confines therapeutic agents for targeted tumor treatment.
• This strategy has the potential to advance the next generation of minimally invasive cancer therapies.