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Osteoking improves OP rat by enhancing HSP90‑β expression.

Yan Sun1, Ran Chen2, Di Zhu1

  • 1Pharmaceutical College and Key Laboratory of Pharmacology for Natural Products of Yunnan Province, Kunming Medical University, Kunming, Yunnan 650500, P.R. China.

International Journal of Molecular Medicine
|April 24, 2020
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Osteoking, a Traditional Chinese Medicine, improves osteoporosis by increasing bone mineral density and enhancing heat shock protein HSP 90-beta expression in rats. This treatment promotes calcium deposition and bone repair, offering a novel therapeutic approach for bone disease.

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Area of Science:

  • Orthopedics and Regenerative Medicine
  • Pharmacology and Traditional Medicine
  • Biochemistry and Molecular Biology

Background:

  • Osteoporosis (OP) is a prevalent chronic bone disease leading to pain and fractures.
  • Osteoking, a Traditional Chinese Medicine, has shown prior efficacy in fracture treatment.
  • Identifying molecular targets is crucial for understanding Osteoking's therapeutic mechanisms in OP.

Purpose of the Study:

  • To investigate the therapeutic effects and underlying mechanisms of Osteoking in a rat model of osteoporosis.
  • To identify key molecular targets of Osteoking in the context of osteoporosis treatment.
  • To evaluate the impact of Osteoking on bone metabolism and microstructure.

Main Methods:

  • Bioinformatics and network pharmacology analyses to identify Osteoking's targets in OP.
  • In vivo studies in osteoporotic rats to assess bone mineral density, bone alkaline phosphatase, and bone microstructure.
  • In vitro studies using rat bone mesenchymal stem cells (rBMSCs) to evaluate calcium deposition.
  • Analysis of heat shock protein HSP 90-beta (HSP90-β) expression levels.

Main Results:

  • Heat shock protein HSP 90-beta (HSP90-β) was identified as a key target of Osteoking in OP.
  • Osteoking treatment significantly increased bone mineral density (BMD) and bone alkaline phosphatase in osteoporotic rats.
  • Osteoking promoted calcium deposition in rBMSCs and improved bone microstructure in vivo.
  • Elevated HSP90-β expression was observed in osteoporotic rats and rBMSCs following Osteoking treatment.

Conclusions:

  • Osteoking treatment effectively improves osteoporosis in rats by enhancing HSP90-β expression.
  • The therapeutic mechanisms of Osteoking involve the activation of the bone morphogenetic protein (BMP) signaling pathway, particularly BMP-2.
  • Osteoking demonstrates potential as a therapeutic agent for osteoporosis, targeting HSP90-β and promoting bone regeneration.