Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Epilepsy and Seizures: Overview01:24

Epilepsy and Seizures: Overview

1.0K
Epilepsy is a chronic neurological disease marked by recurrent, unpredictable seizures. These seizures are caused by abnormal electrical discharges in the brain, leading to behavior, sensation, or consciousness alterations. They can also cause transient impairment of awareness, interfering with daily activities.
Various factors can trigger epilepsy, including genetic factors, brain damage, metabolic causes, and unknown etiology. Diagnosis of epilepsy involves electroencephalography (EEG), which...
1.0K
Seizures: Classification01:13

Seizures: Classification

1.2K
Epilepsy is primarily characterized by unpredictable seizures, either provoked by an identifiable factor, such as injury or illness, or unprovoked, occurring spontaneously without apparent cause.
Seizures are typically classified into two main categories: focal and generalized seizures.
Focal Seizures
Focal seizures originate from specific regions of the brain. These seizures are further sub-classified into two types:
1.2K
Antiepileptic Drugs: Modulators of Neurotransmitter Release Mediated by SV2A Protein01:20

Antiepileptic Drugs: Modulators of Neurotransmitter Release Mediated by SV2A Protein

729
Antiepileptic drugs, such as levetiracetam (Keppra) and brivaracetam (Briviact), have emerged as crucial tools in managing epilepsy. These medications exert their therapeutic effects by targeting the synaptic vesicle protein SV2A, a transmembrane glycoprotein primarily found in the brain.
SV2A is a transmembrane glycoprotein located predominantly in the brain, modulating the release of neurotransmitters for neuronal communication. Both levetiracetam and brivaracetam exhibit a high affinity for...
729
Antiepileptic Drugs: Glutamate Antagonists01:14

Antiepileptic Drugs: Glutamate Antagonists

800
Glutamate is a fundamental neurotransmitter in the central nervous system, playing a vital role in neuronal communication and various cognitive processes. Glutamate stands as the principal excitatory neurotransmitter in the brain. Its presence is crucial for the communication between neurons, underpinning essential processes such as synaptic transmission, neuronal excitability, and plasticity. These functions are vital for higher-order cognitive processes, including learning and memory. The...
800
Electroconvulsive Therapy01:30

Electroconvulsive Therapy

633
Electroconvulsive therapy (ECT), or shock therapy, remains a critical biomedical intervention for severe, treatment-resistant depression. While its origins can be traced back to Hippocrates' observations that malaria-induced convulsions alleviated mental illness, modern ECT has evolved significantly from its earlier, more primitive applications. First introduced in 1938 by Ugo Cerletti and his colleagues, ECT involves inducing controlled seizures using electrical currents. In its early...
633
Antiepileptic Drugs: Potassium Channel Activators01:20

Antiepileptic Drugs: Potassium Channel Activators

528
Ezocgabine or retigabine, an antiepileptic drug of remarkable efficacy, has revolutionized the management of seizures. It is a potassium channel activator, explicitly targeting the family of Q subtype potassium channels. It enhances the transmembrane potassium currents, regulating neuronal excitability. This action stabilizes the resting membrane potential, a pivotal factor in mitigating the hyperexcitability that characterizes epilepsy.
Ezogabine has gained approval as an adjunctive treatment...
528

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[The effect of the start date of cognitive rehabilitation after ischemic stroke on the level of recovery].

Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·2023
Same author

[Assessment of disorders of neurodynamic processes in patients with acute ischemic stroke].

Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·2023
Same author

[Ampakines - a promising approach to neuroprotection].

Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·2022
Same author

[Independence of ischemic stroke patients after alteplase systemic thrombolytic therapy].

Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·2022
Same author

[Dynamics of recovery of cognitive deficit in patients in the early recovery period of ischemic stroke].

Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·2021
Same author

[Cerebral circulation disorders in COVID-19].

Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·2021

Related Experiment Video

Updated: Dec 23, 2025

Electrophoretic Delivery of γ-aminobutyric Acid GABA into Epileptic Focus Prevents Seizures in Mice
07:01

Electrophoretic Delivery of γ-aminobutyric Acid GABA into Epileptic Focus Prevents Seizures in Mice

Published on: May 16, 2019

9.4K

[Remissions and relapses in epilepsy].

A S Kotov1

  • 1Vladimirsky Moscow Regional Research and Clinical Institute, Moscow, Russia.

Zhurnal Nevrologii I Psikhiatrii Imeni S.S. Korsakova
|April 24, 2020
PubMed
Summary

Epilepsy remission patterns vary. Previous remissions, or "honeymoons," predict lower chances of future remission, especially in focal epilepsies, which may lead to intractable epilepsy.

Area of Science:

  • Neurology
  • Clinical Neuroscience

Background:

  • Epilepsy affects millions globally, characterized by recurrent seizures.
  • Understanding remission and relapse patterns is crucial for effective long-term management.

Purpose of the Study:

  • To investigate clinical patterns of seizure remission and subsequent relapse in adult epilepsy patients.
  • To identify predictors of remission and relapse across different epilepsy types.

Main Methods:

  • A cohort study of 1384 adult epilepsy patients.
  • Analysis of 249 patients with a history of remission and subsequent relapse.
  • Stratification into 6 groups based on clinical features for long-term outcome evaluation.

Main Results:

  • Returning to basic therapy post-relapse does not ensure remission.
Keywords:
epilepsyrelapseremission

More Related Videos

Electroconvulsive Seizures in Rats and Fractionation of Their Hippocampi to Examine Seizure-induced Changes in Postsynaptic Density Proteins
09:07

Electroconvulsive Seizures in Rats and Fractionation of Their Hippocampi to Examine Seizure-induced Changes in Postsynaptic Density Proteins

Published on: August 15, 2017

12.5K
Generation and On-Demand Initiation of Acute Ictal Activity in Rodent and Human Tissue
06:45

Generation and On-Demand Initiation of Acute Ictal Activity in Rodent and Human Tissue

Published on: January 19, 2019

9.3K

Related Experiment Videos

Last Updated: Dec 23, 2025

Electrophoretic Delivery of γ-aminobutyric Acid GABA into Epileptic Focus Prevents Seizures in Mice
07:01

Electrophoretic Delivery of γ-aminobutyric Acid GABA into Epileptic Focus Prevents Seizures in Mice

Published on: May 16, 2019

9.4K
Electroconvulsive Seizures in Rats and Fractionation of Their Hippocampi to Examine Seizure-induced Changes in Postsynaptic Density Proteins
09:07

Electroconvulsive Seizures in Rats and Fractionation of Their Hippocampi to Examine Seizure-induced Changes in Postsynaptic Density Proteins

Published on: August 15, 2017

12.5K
Generation and On-Demand Initiation of Acute Ictal Activity in Rodent and Human Tissue
06:45

Generation and On-Demand Initiation of Acute Ictal Activity in Rodent and Human Tissue

Published on: January 19, 2019

9.3K
  • Multiple prior remissions (

    • Conclusions:

    • Prior "honeymoons" in epilepsy history predict a lower likelihood of achieving remission.
    • Focal epilepsies often exhibit long-term remissions independent of antiepileptic drugs (AEDs).
    • Relapse in focal epilepsies can occur in the second decade, potentially leading to intractable epilepsy.