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Published on: July 24, 2016
[Enterovirus meningitis in a child of one month in source of infection]
A S Shishov1, I V Mitrophanova2, T V Kirychenko2
1Chumakov Federal Scientific Center for Research and Development of Immuno-and-Biological Products of Russian Academy of Sciences, Moscow, Russia.
Insights
This case study details a rare instance of enterovirus meningitis in a one-month-old infant. The infant
Area of Science:
- Pediatrics
- Infectious Diseases
- Virology
Background:
- Enterovirus infections are common in children but severe disease like meningitis is rare in infants.
- Coxsackie B viruses are a known cause of enterovirus infections, including meningitis.
- Early diagnosis and management are crucial for favorable outcomes in infant meningitis.
Observation:
- A one-month-old infant presented with enterovirus meningitis confirmed by PCR for Coxsackie B virus.
- The infant's mother, aged 40, also contracted the virus, suggesting a possible transmission route.
- The disease followed a biphasic course in both mother and child, with enterovirus RNA detected in cerebrospinal fluid.
Findings:
- Laboratory confirmation of Coxsackie B1-6 meningitis in a one-month-old infant.
- Detection of enterovirus RNA via PCR in cerebrospinal fluid indicated active infection.
- The case highlights the potential for severe enterovirus disease in young infants, even from mild parental infections.
Implications:
- This case underscores the importance of considering enterovirus meningitis in infants with compatible symptoms.
- Understanding transmission dynamics, even from mild cases in adults, is vital for prevention.
- Further research into clinical presentations and outcomes of enterovirus meningitis in infants is warranted.
Objective:
To describe a rare case of enterovirus disease with meningitis in an infant.
Material And Methods:
Summary of medical records of the child and his mother were used.
Results And Conclusion:
The medical history, characteristics of the clinical picture, the composition of the cerebrospinal fluid (CSF) for laboratory confirmed Coxsackie B1-6 with meningitis in the infant, aged 1 month, and his mother, 40 years old, the source of which were older children who had the infection in the form of a «minor illness», are presented. Enterovirus RNA was detected by PCR in pleocytosis 984/3 on the 4th (in a child) and cytosis 18/3 on the 5th day (in a mother) in the two-wave course of the disease. Data on clinical forms of enterovirus infection in children, aged 0-12 months, the frequency of cases and clinical signs of enterovirus meningitis in infants are considered.
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