Related Experiment Video

Updated: Dec 23, 2025

Microfluidics in Assessing Platelet Function
06:47

Microfluidics in Assessing Platelet Function

Published on: November 8, 2024

1.4K

Severe bleeding caused by piperacillin/tazobactam-induced platelet dysfunction


Bosko Skoric, Antonio Agic, Marijan Pasalic

    International Journal of Clinical Pharmacology and Therapeutics
    |April 24, 2020
    PubMed
    Abstract

    Insights

    Piperacillin/tazobactam can cause bleeding through platelet dysfunction, not just low platelets. This rare complication requires specific platelet function tests for diagnosis.

    Area of Science:

    • Pharmacology
    • Hematology
    • Infectious Diseases

    Background:

    • Piperacillin/tazobactam (TZP) is a critical antibiotic for nosocomial infections caused by multidrug-resistant Pseudomonas.
    • Thrombocytopenia is a recognized complication of TZP therapy.
    • Bleeding complications associated with TZP are typically linked to thrombocytopenia.

    Observation:

    • A 73-year-old male developed severe pulmonary hemorrhage and bloody diarrhea while on TZP for Pseudomonas aeruginosa ventilator-associated pneumonia.
    • Routine platelet counts and coagulation tests were within normal limits.
    • Platelet functional assays revealed impaired ADP-dependent aggregation.

    Findings:

    • This case highlights platelet dysfunction as a rare mechanism for TZP-induced bleeding.
    • This is the second reported instance of TZP-related bleeding due to platelet dysfunction.
    • Unlike thrombocytopenia, platelet dysfunction requires specialized functional tests for detection.

    Implications:

    • Clinicians should consider platelet dysfunction in patients experiencing unexplained bleeding during TZP treatment, even with normal platelet counts.
    • Platelet functional testing is crucial for diagnosing this specific TZP adverse effect.
    • This finding expands the understanding of piperacillin/tazobactam's potential adverse effects beyond thrombocytopenia.

    More Related Videos

    Uncontrolled Hemorrhagic Shock Modeled via Liver Laceration in Mice with Real Time Hemodynamic Monitoring06:11

    Uncontrolled Hemorrhagic Shock Modeled via Liver Laceration in Mice with Real Time Hemodynamic Monitoring

    Published on: May 21, 2017

    9.0K
    Comprehensive Analysis of Procoagulant Platelets Exhibiting Features of Necrosis, Apoptosis and Platelet Activation04:37

    Comprehensive Analysis of Procoagulant Platelets Exhibiting Features of Necrosis, Apoptosis and Platelet Activation

    Published on: May 23, 2025

    941

    Related Concept Videos

    Antiplatelet Drugs: Prostaglandin Synthesis, P2Y12 and Glycoprotein IIb/IIIa Inhibitors01:20

    Antiplatelet Drugs: Prostaglandin Synthesis, P2Y12 and Glycoprotein IIb/IIIa Inhibitors

    Antiplatelet drugs emerge as frontline defenders against the insidious threat of thromboembolic diseases, where abnormal clots obstruct vital blood vessels. These drugs stand as bulwarks, inhibiting platelet aggregation and clot formation, thereby mitigating the risk of life-threatening conditions like myocardial infarction, coronary artery disease, and thrombotic strokes.
    Prostaglandin synthesis inhibitors, exemplified by the widely known aspirin, wield their power by irreversibly acetylating...
    961
    Formation of the Platelet Plug01:22

    Formation of the Platelet Plug

    The platelet phase, the second stage of hemostasis, commences around 15-20 seconds after an injury. It follows and overlaps with the vascular phase, during which blood vessels constrict to minimize blood loss.
    As the injured blood vessel contracts, endothelial cells undergo contraction, revealing collagen fibers in the basement membrane and underlying connective tissue. Furthermore, the plasma membrane of endothelial cells becomes adhesive, preparing the site for platelet adhesion. Platelets...
    8.4K
    Disorders of Hemostasis01:24

    Disorders of Hemostasis

    Hemostasis, the process that stops bleeding after a blood vessel injury, is crucial for maintaining the integrity of the circulatory system. However, disorders of hemostasis can disrupt this delicate balance, leading to either excessive clotting or bleeding. These disorders can be broadly classified into thromboembolic disorders and bleeding disorders.
    Thromboembolic Disorders
    Two factors primarily cause thromboembolic conditions.
    1.8K
    Introduction to Hemostasis01:05

    Introduction to Hemostasis

    Hemostasis is a complex physiological process that prevents excessive bleeding when a blood vessel is injured. It's crucial for maintaining the integrity of the circulatory system, as it ensures that our blood remains fluid while still within the vascular network and yet clots to prevent blood loss upon vessel injury.
    The three phases of hemostasis involve many clotting factors present in plasma and several substances released by platelets and injured tissue cells. It is a fast, localized,...
    12.6K
    Pulmonary Embolism II: Diagnostic Studies and Interprofessional Care01:29

    Pulmonary Embolism II: Diagnostic Studies and Interprofessional Care

    Diagnosing Pulmonary EmbolismDiagnosing pulmonary embolism (PE) involves clinical assessment and advanced imaging tests. The preferred diagnostic tool is the spiral (helical) CT scan or CT angiography (CTA), which uses intravenous contrast media to visualize the pulmonary vasculature and identify emboli.A ventilation-perfusion (V/Q) scan is an alternative for patients unable to receive contrast media. This scan includes both perfusion and ventilation scanning. Perfusion scanning involves...
    192