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Related Concept Videos

Atherosclerosis II: Clinical Manifestations and Diagnostic Tests01:27

Atherosclerosis II: Clinical Manifestations and Diagnostic Tests

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Atherosclerosis is a progressive disorder that leads to the thickening and narrowing of arterial walls due to plaque buildup. This condition can cause various symptoms depending on the arteries affected:Coronary Artery Disease (CAD): This condition affects the coronary arteries and may lead to chest pain (angina), shortness of breath (dyspnea), heart attacks, and other heart disease symptoms.Cerebrovascular Disease: This affects blood flow to the brain, causing transient ischemic attacks (TIAs)...
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Atherosclerosis III: Management01:26

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Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...
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Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...
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Coronary Artery Disease I: Introduction01:30

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Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
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Assessing blood pressure is a standard procedure executed in virtually all medical environments. The method utilized today was established over a hundred years ago by an innovative Russian doctor, Dr. Nikolai Korotkoff. The soft ticking noise, known as Korotkoff sounds, heard while taking blood pressure readings results from turbulent blood flow within the vessels. The apparatus required for this procedure includes a sphygmomanometer, a blood pressure cuff attached to a gauge, and a...
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Nursing management for a patient with arteriosclerosis involves a comprehensive approach focusing on lifestyle modification, disease monitoring, education, and symptomatic care. Here is an overview of effective nursing strategies:Assessment and Monitoring: Initial and ongoing assessments are crucial. Nurses must document the patient's medical history, including any hypertension, diabetes, hyperlipidemia, and other cardiovascular diseases. Assessments also cover family history and lifestyle...
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Quantification of Atherosclerosis in Mice
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Reimagining What We Measure in Atherosclerosis-a "Phenotype Stack".

Calum A MacRae1,2, Robert M Califf1,3,4

  • 1From the One Brave Idea (C.A.M., R.M.C.).

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|April 24, 2020
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Summary

Modern technology promises a phenotyping revolution, enhancing biological understanding and clinical care. This shift requires a new scale in biomedicine for better discovery and patient outcomes.

Keywords:
atherosclerosisgenotypephenotypepublic healthtranslation

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Area of Science:

  • Genomics and Precision Medicine
  • Developmental Biology
  • Behavioral Science

Background:

  • The definition of phenotype, observable characteristics from genotype-environment interaction, lacks a universal understanding.
  • Current phenotyping methods are limited by measurement deficits, computational constraints, and a lack of generalizability.
  • Existing approaches struggle to capture the complexity of biological phenomena and human traits.

Purpose of the Study:

  • To explore the potential of modern technology to revolutionize phenotyping.
  • To outline the necessary changes in scale and approach for a new era of phenotyping.
  • To highlight the implications of advanced phenotyping for biological discovery, clinical care, and public health.

Main Methods:

  • Leveraging modern technological advancements for comprehensive phenotyping.
  • Integrating traditional and novel methods for structured data collection.
  • Analyzing biological and behavioral data at an unprecedented scale.

Main Results:

  • Modern technology offers the potential for a paradigm shift in phenotyping.
  • Structured, large-scale phenotyping can significantly advance basic biology and behavior understanding.
  • Improved phenotyping capabilities are expected to enhance clinical care and public health outcomes.

Conclusions:

  • A revolution in phenotyping is achievable through technological integration and a change in scale.
  • This transformation necessitates a radical shift in biomedical operations and the unit of action.
  • The implications for medical care, translational research, and scientific discovery are profound.