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Noncoding RNAs in Vascular Diseases.

Nicolas Jaé1, Stefanie Dimmeler1,2,3

  • 1From the Institute for Cardiovascular Regeneration (N.J., S.D.), Goethe University Frankfurt, Germany.

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|April 24, 2020
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Summary
This summary is machine-generated.

Deep sequencing reveals noncoding RNAs regulate cardiovascular diseases. This review highlights microRNAs, circular RNAs, and long noncoding RNAs for potential therapeutic strategies in vascular conditions.

Keywords:
arteriosclerosiscircRNAendothelial cellsinflammationlong noncoding RNAmicroRNAs

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Area of Science:

  • Molecular Biology
  • Genetics
  • Cardiovascular Research

Background:

  • Deep sequencing has identified numerous noncoding RNA transcripts.
  • Noncoding RNAs play crucial roles in regulating cardiovascular diseases.
  • MicroRNAs are well-studied, with potential for therapeutic targeting in vascular conditions.

Purpose of the Study:

  • To provide an overview of noncoding RNAs controlling the vasculature.
  • To focus on the emerging field of long noncoding RNAs in vascular diseases.

Main Methods:

  • Review of existing literature on noncoding RNAs and cardiovascular diseases.
  • Analysis of studies investigating the in vivo functions of various noncoding RNA types.

Main Results:

  • MicroRNAs have established roles as vasculoprotective or detrimental species.
  • Circular RNAs, YRNAs, and long noncoding RNAs are gaining attention for their roles in vascular diseases.
  • Emerging evidence suggests these noncoding RNAs act as mediators or antagonists in vivo.

Conclusions:

  • Noncoding RNAs represent a significant area for understanding and treating cardiovascular diseases.
  • Long noncoding RNAs are a promising area for future research and therapeutic development in vascular medicine.