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Updated: Jul 30, 2026

Assessment of Blood-brain Barrier Permeability by Intravenous Infusion of FITC-labeled Albumin in a Mouse Model of Neurodegenerative Disease
Published on: November 8, 2017
[Qualitative changes in cerebrospinal fluid albumin in cerebral stroke]
Abstract:
Isoelectrical focusing in borate-polyol systems has been used in studies on physico-chemical properties of albumin in the cerebrospinal fluid (CSF) of patients with cerebral stroke. The acute stage of stroke was characterized by an increase in alkaline fractions of CSF albumin with the isoelectrical point (pI) of 5.27-7.4. There is correlation between the levels of alkaline fractions with pI 5.2-7.4 and the severity of patients' status. The method does not help differentiate the nature of stroke but is of a definite prognostic value and characterizes the depth of pathomorphological brain alterations.
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