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Related Concept Videos

Inflammatory Bowel Disease I: Ulcerative Colitis01:27

Inflammatory Bowel Disease I: Ulcerative Colitis

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Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
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Drugs for Treatment of Ulcerative Colitis in IBD01:29

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Ulcerative colitis is a chronic inflammatory condition primarily affecting the colon and rectum. The primary drugs used in the treatment of ulcerative colitis are aminosalicylates. They exhibit anti-inflammatory and immunosuppressive properties. They modulate inflammatory mediators and inhibit the activity of nuclear factor κB (NF-κB). Aminosalicylates also reduce inflammation by inhibiting prostaglandin and leukotriene production and decreasing neutrophil chemotaxis and superoxide...
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Related Experiment Video

Updated: Dec 23, 2025

Systematic Scoring Analysis for Intestinal Inflammation in a Murine Dextran Sodium Sulfate-Induced Colitis Model
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Ulcerative Colitis: A Critical Approach to the Global Research Output Employing Density-equalizing Mapping and

Norman Schöffel1,2, Dörthe Brüggmann1,3, Doris Klingelhöfer1

  • 1Department of Preventive Medicine, Institute of Occupational Medicine, Social Medicine and Environmental Medicine, Goethe-University, Frankfurt.

Journal of Clinical Gastroenterology
|April 24, 2020
PubMed
Summary
This summary is machine-generated.

Scientometric analysis reveals the United States, Germany, and the UK lead ulcerative colitis (UC) research. International collaborations are crucial for advancing scientific progress in UC.

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Area of Science:

  • Gastroenterology and Inflammatory Bowel Disease Research

Background:

  • Ulcerative colitis (UC) research faces challenges due to a vast publication volume (>40,000 since 1900).
  • A comprehensive understanding of the global UC research landscape and collaborative networks is currently lacking.

Purpose of the Study:

  • To conduct a scientometric study of global research activity in ulcerative colitis (UC).
  • To quantify research productivity, scientific output, and collaborative networks in the UC field.

Main Methods:

  • Utilized the NewQIS (New Quality and Quantity Indices in Science) platform for scientometric analysis.
  • Assessed research productivity, country/institution/author/journal output, and collaborations.
  • Employed density-equalizing mapping projections for data visualization.

Main Results:

  • The United States, Germany, and the United Kingdom are identified as leading countries in UC research.
  • UC research has diversified across numerous subject areas over recent decades.
  • International collaborations are confirmed as a key driver of scientific progress in UC.

Conclusions:

  • Scientometrics provide a valuable method for evaluating quantitative and semiqualitative aspects of UC research.
  • The impact of international cooperation on scientific advancement in ulcerative colitis is continually increasing.