The involvement of crustaceans toll-like receptors in pathogen recognition

Crustacean species are considered as a major sector in the aquaculture industry that plays a fundamental role in the world's economy. However, with a wide range of various epidemic diseases in the industry, studies of immune-related genes such as toll-like receptor genes are of great importance. Recently, the TLR in crustacean species has been described to perform a vital role in defense of crustacean against the pathogens. Meanwhile, many TLR genes from crustacean were characterized, and their contribution discovered in innate immunity against several pathogens. This review was aimed to present an overview of the crustacean TLRs including structural features that contained three major domains: a leucine-rich repeat (LRR) domains, a transmembrane area (TM), and a conserved region called Toll/interleukin-1 receptor (TIR) domain. The tissue distribution patterns of TLR genes, which act as a guide for future research on which TLR gene or genes that can be expressed, at which tissue or tissues. We also described recent works on the expression of the TLR gene that evaluated the immune function after pathogen stimulation in shrimp, crab, and crayfish. Furthermore, we recommended a prospective for future investigation plan that might contribute to the development and management systems in the global crustacean aquaculture industry. Lastly, we assumed that a clear understanding of the expression pattern and biological function of crustacean TLR genes could serve as a baseline for future immunological studies.