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Metabolic Regulation of Myeloid-Derived Suppressor Cell Function in Cancer

Yufei Wang1, Anna Jia1, Yujing Bi2

  • 1Key Laboratory of Cell Proliferation and Regulation Biology, Ministry of Education, Institute of Cell Biology, College of Life Sciences, Beijing Normal University, Beijing 100875, China.

Cells
|April 25, 2020
PubMed

Insights

Myeloid-derived suppressor cells (MDSCs) are key immunosuppressive cells in cancer. Their metabolic reprogramming in the tumor microenvironment enhances tumor growth and immune evasion.

Area of Science:

  • Immunology
  • Cancer Biology
  • Metabolism

Background:

  • Myeloid-derived suppressor cells (MDSCs) are critical immunosuppressive cells in cancer.
  • MDSCs promote tumor growth and immune evasion in cancer patients and mice.
  • MDSC metabolic activity is increasingly recognized as a key regulator of their function.

Purpose of the Study:

  • To summarize recent advancements in understanding MDSC metabolic reprogramming.
  • To elucidate the link between MDSC metabolism and their immunosuppressive functions during tumorigenesis.

Main Methods:

  • Literature review of studies on MDSC metabolism and function in cancer.
  • Analysis of metabolic pathways (glycolysis, fatty acid oxidation, amino acid metabolism) in MDSCs within the tumor microenvironment.

Main Results:

  • MDSC metabolism is significantly reprogrammed within the tumor microenvironment.
  • Metabolic reprogramming enhances MDSC immunosuppressive activity.
  • This leads to effector T cell apoptosis and proliferation of suppressive cells.

Conclusions:

  • Metabolic reprogramming is a crucial mechanism by which MDSCs promote cancer progression.
  • Targeting MDSC metabolism represents a potential therapeutic strategy in oncology.
Keywords:
MDSCscancercell differentiationimmune cell differentiationimmunotherapymetabolism signaling pathwaymyeloid-derived suppressor cellstumor immunotherapy

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