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Ultraweak Photon Emissions as a Non-Invasive, Early-Malignancy Detection Tool: An In Vitro and In Vivo Study.

Nirosha J Murugan1,2, Michael A Persinger1,3, Lukasz M Karbowski1

  • 1Behavioural Neuroscience & Biomolecular Science, Laurentian University, 935 Ramsey Lake Road, Sudbury, ON P3E 2C6, Canada.

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Ultraweak photon emissions (UPE) can detect cancer early. Malignant cells show higher UPE, enabling differentiation from healthy cells with 90% accuracy in cell cultures and mice.

Keywords:
cancer diagnosticsdiscriminant functionsmalignancymice developing tumorspancreatic cell culturesultraweak photon emission

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Area of Science:

  • Biophysics
  • Oncology
  • Medical Diagnostics

Background:

  • Early cancer detection significantly improves patient outcomes and survival rates.
  • Previous research indicated ultraweak photon emissions (UPE) as a potential biomarker for cancer detection.
  • A need exists for reliable methods for early cancer detection in both in vitro and in vivo models.

Purpose of the Study:

  • To develop and validate an early cancer detection protocol using ultraweak photon emissions (UPE).
  • To assess the feasibility of differentiating malignant from non-malignant cells and tumors based on UPE.
  • To investigate the diagnostic accuracy and spectral characteristics of UPE in cancer detection.

Main Methods:

  • Photon emissions were measured from ~1 million malignant and non-malignant cells across 13 human and mouse cell lines.
  • Spectral Power Density (SPD) was analyzed for flux densities between 0.1 and 25 Hz.
  • Emission profiles of mice injected with melanoma cells were compared to non-malignant controls.

Main Results:

  • Malignant cells exhibited significantly higher photon emissions compared to non-malignant cells.
  • The standardized SPD analysis achieved 90% discriminant accuracy for malignancy detection.
  • UPE profiles differentiated tumor-bearing mice from controls as early as 24 hours post-injection, with a peak SPD around 20 Hz.

Conclusions:

  • Ultraweak photon emissions provide a viable method for early cancer detection.
  • The distinct spectral profile, particularly around 20 Hz, holds diagnostic potential for malignancy.
  • These findings support and extend previous research on UPE as a non-invasive cancer diagnostic tool.