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Updated: Dec 23, 2025

A Macrophage-Tumor Spheroid Co-Invasion Assay
Published on: January 24, 2025
Contribution of Macrophages and T Cells in Skeletal Metastasis
Veronica Mendoza-Reinoso1, Laurie K McCauley1,2, Pierrick G J Fournier3
1Department of Periodontics and Oral Medicine, University of Michigan School of Dentistry, Ann Arbor, MI 48109, USA.
Abstract:
Bone is a common site for metastases with a local microenvironment that is highly conducive for tumor establishment and growth. The bone marrow is replete with myeloid and lymphoid linage cells that provide a fertile niche for metastatic cancer cells promoting their survival and growth. Here, we discuss the role of macrophages and T cells in pro- and anti-tumoral mechanisms, their interaction to support cancer cell growth, and their contribution to the development of skeletal metastases. Importantly, immunotherapeutic strategies targeting macrophages and T cells in cancer are also discussed in this review as they represent a great promise for patients suffering from incurable bone metastases.
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