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A Restriction Enzyme Based Cloning Method to Assess the In vitro Replication Capacity of HIV-1 Subtype C Gag-MJ4 Chimeric Viruses
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Role of Divalent Cations in HIV-1 Replication and Pathogenicity
Nabab Khan1, Xuesong Chen1, Jonathan D Geiger1
1Department of Biomedical Sciences, University of North Dakota School of Medicine and Health Sciences, Grand Forks, ND 58203, USA.
Viruses
|April 25, 2020
Summary
Divalent cations impact human immunodeficiency virus type-1 (HIV-1) replication. Modulating these essential minerals may offer new therapeutic strategies for HIV-1 management.
Area of Science:
- Biochemistry
- Virology
- Immunology
Background:
- Divalent cations are crucial for cellular processes, including metabolism, growth, and host-pathogen interactions.
- These cations play a key role in human immunodeficiency virus type-1 (HIV-1) replication and pathogenicity by mediating viral and host factor interactions.
Purpose of the Study:
- To review the literature on the roles of specific divalent cations (zinc, iron, manganese, magnesium, selenium, copper) in HIV-1 replication and pathogenicity.
- To explore the potential of targeting divalent cation homeostasis as a therapeutic strategy for HIV-1 infection.
Main Methods:
- Literature review of scientific articles and studies.
- Analysis of the impact of various divalent cations on HIV-1 replication and disease progression.
- Examination of evidence for therapeutic interventions involving cation modulation.
Main Results:
- Divalent cation levels and their actions are altered during HIV-1 infection.
- Dietary supplementation with divalent cations may enhance HIV-1 replication.
- Cation chelation shows potential in suppressing HIV-1 replication and slowing disease progression.
Conclusions:
- Divalent cations are critical regulators in HIV-1 pathogenesis.
- Therapeutic strategies targeting divalent cation balance represent a promising avenue for managing HIV-1 infection and progression.
Keywords:
HIV-1 associated neurocognitive disordersdivalent cationsendolysosomeshuman immunodeficiency virus type-1transactivator of transcriptionMore Related Videos
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