Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test01:22

Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test

120
In clinical practice, the direct measurement of hepatic blood flow to evaluate liver function presents significant challenges due to the intricate and specialized nature of the necessary techniques. Consequently, healthcare professionals often rely on empirical estimates derived from thorough patient examinations and liver function tests to gauge liver health. Among the tools at their disposal, the Child–Pugh and MELD scoring systems stand out for their ability to categorize and assess...
120
Effect of Hepatic Disease on Pharmacokinetics: Drug Dosing and Hepatic Blood Flow01:26

Effect of Hepatic Disease on Pharmacokinetics: Drug Dosing and Hepatic Blood Flow

158
Chronic liver disease significantly impacts drug metabolism due to alterations in hepatic blood flow and enzyme accessibility. This disruption affects the body's pharmacokinetics—the movement and processing of drugs within the system. Key enzymes crucial for metabolizing medications become less accessible, changing how drugs are processed and utilized. Furthermore, liver disease influences the synthesis of plasma proteins, such as albumin and globulins, which play critical roles in drug...
158
Esophageal Varices-II: Clinical Features and Management01:28

Esophageal Varices-II: Clinical Features and Management

299
Esophageal varices often manifest as gastrointestinal bleeding episodes, presenting symptoms like hematemesis (vomiting of blood), hematochezia (passing fresh blood via the rectum), and melena (black, tarry stools). Other signs can include weight loss, anorexia, abdominal discomfort, jaundice, pruritus, altered mental status, and muscle cramps.
In the initial assessment, a thorough review of the patient's medical history is vital to identify risk factors such as liver disease, alcohol...
299
Liver Physiology01:30

Liver Physiology

3.4K
The liver, an essential organ in the human body, performs over 200 vital functions that can be broadly categorized into metabolic, hematological, endocrine regulation, and bile production.
Metabolic Regulation:
The liver is the central organ involved in regulating blood composition. It stabilizes blood glucose levels, maintaining them within the range of  70–110 mg/dL. When these levels drop, the liver breaks down glycogen reserves and releases glucose into the bloodstream. It can...
3.4K
Inflammatory Bowel Disease I: Ulcerative Colitis01:27

Inflammatory Bowel Disease I: Ulcerative Colitis

765
Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
765
Liver Regeneration01:24

Liver Regeneration

4.1K
The liver is an important organ in vertebrates that plays an essential role in metabolism. It is also responsible for storing and redistributing nutrients such as carbohydrates, fats, and vitamins in the body. Additionally, the liver releases bile salts which are critical for digesting food and eliminating toxic metabolites from the body.
Cells of Liver
The liver comprises four major types of cells— hepatocytes, stellate, Kupffer, and sinusoidal endothelial cells. The hepatocytes are...
4.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The crosstalk between gut microbiota and microbiota-derived metabolites in hepatocellular carcinoma.

Critical reviews in microbiology·2025
Same author

Procalcitonin and C-Reactive Protein as Diagnostic Biomarkers for Bacterial Gastroenteritis: A Retrospective Analysis.

Journal of clinical medicine·2025
Same author

Clinical Features of Impacted Common Bile Duct Stones at Duodenal Papilla.

The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi·2024
Same author

Association between Atherosclerosis and High-Risk Colorectal Adenomas based on Cardio-Ankle Vascular Index and Ankle-Brachial Index.

The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi·2024
Same author

Novel management of expected post-radiotherapy complications in hepatocellular carcinoma patients: a case report.

Journal of liver cancer·2023
Same author

Outcome of Intermittent Thoracentesis versus Pigtail Catheter Drainage for Hepatic Hydrothorax.

Journal of clinical medicine·2022

Related Experiment Video

Updated: Dec 23, 2025

Two-photon Intravital Imaging of Leukocytes During the Immune Response in Lipopolysaccharide-treated Mouse Liver
07:06

Two-photon Intravital Imaging of Leukocytes During the Immune Response in Lipopolysaccharide-treated Mouse Liver

Published on: February 6, 2018

10.7K

Liver Dysfunction in Sepsis.

Tae Suk Kim1, Dae Hee Choi1

  • 1Department of Internal Medicine, Kangwon National University School of Medicine, Chuncheon, Korea.

The Korean Journal of Gastroenterology = Taehan Sohwagi Hakhoe Chi
|April 25, 2020
PubMed
Summary

Sepsis, a life-threatening organ dysfunction, impacts the liver significantly. This review examines sepsis definitions and liver injury, particularly in cirrhosis patients, assessing Sepsis-3 criteria applicability.

Keywords:
InfectionsLiver cirrhosisMultiple organ failureSepsis-3

More Related Videos

Cecal Ligation Puncture Procedure
11:53

Cecal Ligation Puncture Procedure

Published on: May 7, 2011

56.0K
Use of Animal Model of Sepsis to Evaluate Novel Herbal Therapies
07:34

Use of Animal Model of Sepsis to Evaluate Novel Herbal Therapies

Published on: April 11, 2012

20.0K

Related Experiment Videos

Last Updated: Dec 23, 2025

Two-photon Intravital Imaging of Leukocytes During the Immune Response in Lipopolysaccharide-treated Mouse Liver
07:06

Two-photon Intravital Imaging of Leukocytes During the Immune Response in Lipopolysaccharide-treated Mouse Liver

Published on: February 6, 2018

10.7K
Cecal Ligation Puncture Procedure
11:53

Cecal Ligation Puncture Procedure

Published on: May 7, 2011

56.0K
Use of Animal Model of Sepsis to Evaluate Novel Herbal Therapies
07:34

Use of Animal Model of Sepsis to Evaluate Novel Herbal Therapies

Published on: April 11, 2012

20.0K

Area of Science:

  • Hepatology
  • Infectious Diseases
  • Critical Care Medicine

Background:

  • Sepsis involves life-threatening organ dysfunction due to infection.
  • The liver plays crucial roles in immune defense and metabolic adaptation during sepsis.
  • Sepsis can cause liver injury, including hypoxic hepatitis and cholestasis, with higher mortality in cirrhosis patients.

Purpose of the Study:

  • To review sepsis pathogenesis and liver dysfunction.
  • To summarize the Sepsis-3 definition and its clinical applicability in cirrhotic patients.

Main Methods:

  • Literature review of sepsis definitions, pathogenesis, and liver injury.
  • Analysis of Sepsis-3 criteria (SOFA and qSOFA scores) in the context of cirrhosis.

Main Results:

  • Sepsis-3 relies on organ dysfunction (SOFA/qSOFA) rather than SIRS criteria.
  • The utility of qSOFA in cirrhotic patients requires further investigation.
  • Cirrhosis increases sepsis-related mortality, necessitating prompt diagnosis and treatment.

Conclusions:

  • Understanding sepsis-related liver dysfunction is critical, especially in cirrhosis.
  • The applicability of Sepsis-3 criteria in cirrhotic patients needs further evaluation.
  • Early recognition and management of sepsis in cirrhosis patients are vital for improved outcomes.