The effect of systemic inflammation indexes and ¹⁸FDG PET metabolic parameters on survival in advanced lung...

To determine the effect of systemic inflammation indexes and fluorine-18 fluorodeoxyglucose (¹⁸FDG) positron emission tomography (PET) metabolic parameters on survival in advanced lung adenocarcinoma.

A total of 133 patients who underwent ¹⁸FDG PET for initial staging were investigated retrospectively. Baseline patient characteristics, routine blood test results, ¹⁸FDG PET metabolic parameters, and treatment history were examined. Overall survival (OS) was demonstrated by Kaplan-Meier analysis, and the curves were compared by the log-rank test. Systemic inflammation response index (SIRI) was defined as neutrophil x monocyte/lymphocyte count.

Lymphocyte/monocyte ratio (LMR) and SIRI were found to be significant for OS. The cutoff point was 2.25 for LMR. Median OS was 8 months for ⩽2.25 and 14 months for >2.25 (p = 0.005). For SIRI, the cutoff point was 2. SIRI ⩽2 was associated with a median OS of 16 months compared to 10 months for patients with SIRI >2 (p = 0.043). Maximum of standardized uptake value, total lesion glycolysis, and metabolic tumor volume were not found to be significant for OS (p = 0.225, p = 0.061, p = 0.355, respectively). No correlation was found between inflammatory indexes and PET metabolic parameters.

Age and LMR parameters were prognostic for survival in Cox regression analysis. There was no correlation between ¹⁸FDG PET parameters and inflammatory indexes.