Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Humanistic Therapy01:24

Humanistic Therapy

267
Humanistic therapies emphasize personal growth, self-understanding, and the fulfillment of human potential. Rooted in the belief that individuals inherently strive toward self-actualization, these approaches encourage clients to explore their feelings and experiences in a supportive, nonjudgmental environment. Humanistic therapies differ from psychodynamic approaches by focusing on conscious experiences, present circumstances, and the potential for self-improvement rather than past conflicts...
267
Psychotherapy01:28

Psychotherapy

406
Psychotherapy is a versatile, nonmedical approach aimed at helping individuals address emotional, behavioral, and interpersonal issues to enhance their overall well-being. It can involve one-on-one sessions, couples counseling, or small group discussions with a therapist. The therapeutic process includes various techniques such as open discussion, interpretation of thoughts and behaviors, active listening, positive reinforcement, and role modeling. Psychotherapy aims to support individuals in...
406
Psychodynamic Therapy01:29

Psychodynamic Therapy

396
Psychodynamic therapies emphasize the exploration of unconscious processes and early childhood experiences as fundamental contributors to psychological difficulties. These therapies, deeply rooted in Freud's psychoanalytic theory, aim to uncover and resolve unconscious conflicts, granting individuals insights that promote emotional and behavioral healing. Contemporary psychodynamic approaches have evolved, integrating a broader range of influences and methodologies while still valuing the...
396
Modeling in Therapy01:26

Modeling in Therapy

325
Modeling, a key technique in therapy, uses observational learning to help clients acquire and practice new skills by watching therapists demonstrate desired behaviors. This approach, rooted in Albert Bandura's concept of vicarious learning, plays a significant role in therapeutic interventions for various psychological conditions, including social anxiety, ADHD, and depression.
Participant Modeling
Participant modeling involves therapists demonstrating calm and effective behaviors in...
325
Group Therapy01:26

Group Therapy

283
Group therapy is a sociocultural approach to psychological treatment, where individuals with shared psychological challenges come together under the guidance of a mental health professional. This therapeutic modality offers unique opportunities for individuals to connect, share, and grow within the context of a supportive group. By fostering mutual understanding and collaboration, group therapy can address a range of psychological concerns effectively, often complementing or surpassing the...
283
Interpersonal Psychotherapy01:25

Interpersonal Psychotherapy

237
Interpersonal psychotherapy (IPT) is a structured, time-limited therapeutic approach initially developed to treat depression. It integrates key concepts from psychodynamic, humanistic, and cognitive-behavioral therapies, making it a uniquely eclectic framework. The therapy is rooted in the interpersonal theories of Adolph Meyer and Harry Stack Sullivan, as well as John Bowlby's attachment theory, and focuses on the interplay between interpersonal relationships and emotional well-being.
237

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Clinical practice review of systemic treatment in large cell neuroendocrine carcinoma.

Translational lung cancer research·2026
Same author

Outcomes of Concurrent Radiotherapy With Tarlatamab in Extensive-Stage Small Cell Lung Cancer From the DLL3 PanTUMOR Database.

Clinical lung cancer·2026
Same author

Editorial Expression of Concern: Rationale for co-targeting IGF-1R and ALK in ALK fusion-positive lung cancer.

Nature medicine·2025
Same author

Impact of Using Corticosteroid Prophylaxis to Prevent Tumor Flare Reactions During <sup>177</sup>Lu-DOTATATE Treatment in Patients with Neuroendocrine Tumors.

Cancers·2025
Same author

Outcomes Following First-Line Immune Checkpoint Inhibitors With or Without Chemotherapy Stratified by KRAS Mutational Status-A Real-World Analysis in Patients With Advanced NSCLC.

Clinical lung cancer·2025
Same author

Afatinib and Necitumumab in <i>EGFR</i>-Mutant NSCLC with Acquired Resistance to Tyrosine Kinase Inhibitors.

JTO clinical and research reports·2025

Related Experiment Video

Updated: Dec 23, 2025

Using Visual and Narrative Methods to Achieve Fair Process in Clinical Care
14:32

Using Visual and Narrative Methods to Achieve Fair Process in Clinical Care

Published on: February 16, 2011

24.2K

Current Landscape of Personalized Therapy.

Leora Horn1, Amanda S Cass2

  • 1Vanderbilt Ingram Cancer Center, Vanderbilt University Medical Center, 2220 Pierce Avenue, 777 Preston Research Building, Nashville, TN 37205, USA. Electronic address: https://twitter.com/HornLeora.

Thoracic Surgery Clinics
|April 25, 2020
PubMed
Summary

Nearly half of non-small-cell lung cancer (NSCLC) patients have incurable disease at diagnosis. Treatment selection for NSCLC involves histology, molecular testing, and PD-L1 status, with ongoing research for better therapies.

Keywords:
Anaplastic lymphoma kinaseEpidermal growth factor receptorImmune checkpoint inhibitionNon–small-cell lung cancerTargeted therapies

More Related Videos

Photorealistic Learned Landscapes for Augmented Reality
06:54

Photorealistic Learned Landscapes for Augmented Reality

Published on: June 27, 2025

590
Author Spotlight: Therapeutic Benefit of Closed-Loop Deep Brain Stimulation in Depression Treatment
05:19

Author Spotlight: Therapeutic Benefit of Closed-Loop Deep Brain Stimulation in Depression Treatment

Published on: July 7, 2023

3.1K

Related Experiment Videos

Last Updated: Dec 23, 2025

Using Visual and Narrative Methods to Achieve Fair Process in Clinical Care
14:32

Using Visual and Narrative Methods to Achieve Fair Process in Clinical Care

Published on: February 16, 2011

24.2K
Photorealistic Learned Landscapes for Augmented Reality
06:54

Photorealistic Learned Landscapes for Augmented Reality

Published on: June 27, 2025

590
Author Spotlight: Therapeutic Benefit of Closed-Loop Deep Brain Stimulation in Depression Treatment
05:19

Author Spotlight: Therapeutic Benefit of Closed-Loop Deep Brain Stimulation in Depression Treatment

Published on: July 7, 2023

3.1K

Area of Science:

  • Oncology
  • Medical Oncology
  • Thoracic Oncology

Background:

  • Non-small-cell lung cancer (NSCLC) frequently presents as incurable disease or recurs after initial treatment.
  • Current NSCLC systemic therapy selection relies on histology, molecular profiling, and PD-L1 expression.
  • Immunotherapy and targeted therapies offer treatment options based on specific biomarkers.

Purpose of the Study:

  • To review the current landscape of systemic therapy selection for non-small-cell lung cancer.
  • To highlight the role of molecular testing and PD-L1 scoring in guiding treatment decisions.
  • To identify unmet needs and future research directions in NSCLC systemic therapy.

Main Methods:

  • Literature review of current systemic therapy approaches for NSCLC.
  • Analysis of treatment stratification based on tumor histology, molecular alterations, and PD-L1 expression.
  • Discussion of emerging therapeutic strategies and challenges in NSCLC management.

Main Results:

  • Approximately 50% of non-squamous NSCLC patients harbor targetable driver mutations.
  • PD-L1 expression levels dictate eligibility for first-line immunotherapy or chemo-immunotherapy.
  • Resistance to targeted agents and immunotherapy remains a significant clinical challenge.

Conclusions:

  • Systemic therapy for NSCLC is increasingly personalized based on molecular and immune biomarkers.
  • Further development of novel agents with improved efficacy, reduced toxicity, and better CNS penetration is crucial.
  • Addressing treatment resistance is a key priority for advancing NSCLC patient outcomes.