Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Determination of Multiple Dosing Parameters: Loading and Maintenance Doses01:25

Determination of Multiple Dosing Parameters: Loading and Maintenance Doses

136
A loading dose is an essential pharmacological strategy to rapidly achieve the target plasma drug concentration necessary for an immediate therapeutic effect. This approach is especially critical for drugs characterized by slow absorption or extended half-lives, where delaying therapeutic plasma levels could compromise treatment outcomes. By administering a loading dose, clinicians ensure a prompt onset of drug action, even for agents with complex pharmacokinetic profiles.Achieving steady-state...
136
Drug Accumulation During Multiple Dosing: Repetitive IV Injections01:21

Drug Accumulation During Multiple Dosing: Repetitive IV Injections

187
Calculating drug dosage and accumulation in multiple-dose regimens is crucial for achieving therapeutic efficacy while avoiding toxicity. This involves determining the plasma drug concentrations over time to optimize dosing schedules. The principle of superposition is fundamental in this process, allowing for the prediction of drug concentration in plasma following multiple doses based on single-dose data.The principle of superposition asserts that the plasma concentration-time curves from...
187
Dosage Regimens: Partial Pharmacokinetic Parameters01:01

Dosage Regimens: Partial Pharmacokinetic Parameters

96
It is not uncommon for complete drug pharmacokinetic profiles to remain elusive in pharmacokinetics. This necessitates certain educated assumptions by pharmacokineticists to determine appropriate dosage regimens without comprehensive pharmacokinetic data from animal or human studies. One prevalent assumption is setting the bioavailability factor, denoted as F, to 1 or 100%. This assumption caters to the scenario where a drug doesn't achieve full systemic absorption, resulting in the patient...
96
Bioavailability Study Design: Single Versus Multiple Dose Studies01:11

Bioavailability Study Design: Single Versus Multiple Dose Studies

136
Bioavailability studies are essential for understanding how a drug is absorbed, distributed, metabolized, and excreted in the body. These studies assess the extent and rate at which the active pharmaceutical agent becomes available at the site of action. The design of bioavailability studies can involve single-dose or multiple-dose regimens, each with distinct advantages and limitations.Single-dose studies are the preferred approach due to their simplicity and reduced drug exposure for...
136
Analysis of Population Pharmacokinetic Data01:12

Analysis of Population Pharmacokinetic Data

607
Analysis of population pharmacokinetic data involves studying the behavior of drugs within diverse populations to understand their pharmacokinetic parameters. Traditional pharmacokinetic methods typically involve collecting samples from a few individuals and estimating these parameters. While these methods are commonly used, they have limitations in capturing the variability in drug response among individuals or heterogeneous populations. Population pharmacokinetics is employed to address these...
607
Dose Size and Dosing Frequency: Determination Methods01:21

Dose Size and Dosing Frequency: Determination Methods

177
Determining the optimal dose size and dosing frequency in pharmacotherapy is crucial for achieving therapeutic effectiveness while minimizing adverse effects. This article explores the methodologies employed in determining these parameters, focusing on their significance and interplay to tailor dosing regimens.Dose Size: Dose size refers to the amount of a drug administered in a single dose. It is determined based on the drug's pharmacodynamics and pharmacokinetics properties and...
177

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Dynamic shift in the dominant transmission route of clade Ib monkeypox virus across networks with sexual and nonsexual contacts.

Science advances·2026
Same author

The changing mortality burden of measles, pertussis, and diarrheal disease in Amsterdam, 1856-1920.

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases·2026
Same author

Estimation of the epidemiological characteristics of scabies.

Nature communications·2025
Same author

Estimating the effectiveness of non-pharmaceutical interventions against COVID-19 transmission in the Netherlands.

PLoS computational biology·2025
Same author

Seasonal variation in SARS-CoV-2 transmission in The Netherlands, 2020-2022: statistical evidence for an inverse association with solar radiation and temperature.

Journal of the Royal Society, Interface·2025
Same author

Combining mpox vaccination and behavioural changes to control possible future mpox resurgence among men who have sex with men: a mathematical modelling study.

BMJ public health·2025
Same journal

Advance Multi-Priority, Multi-Appointment Patient Scheduling With Dependent Demand and Lead Times.

Production and operations management·2026
Same journal

An Investigation into Demographic Disparities in Emergency Department Disposition Decisions.

Production and operations management·2026
Same journal

No Country for Young Refugees: Barriers and Opportunities for Inclusive Refugee Education Practices.

Production and operations management·2026
Same journal

Political Uncertainty and the Timing of Mass Layoffs.

Production and operations management·2026
Same journal

Translating Empirical State-Dependent Service Times Into Queueing Models.

Production and operations management·2026
Same journal

Multi-Agent Deep Reinforcement Learning for Multi-Echelon Inventory Management.

Production and operations management·2026
See all related articles

Related Experiment Video

Updated: Dec 23, 2025

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies
08:34

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

Published on: February 6, 2019

20.9K

Dose-Optimal Vaccine Allocation over Multiple Populations.

Lotty E Duijzer1, Willem L van Jaarsveld2, Jacco Wallinga3

  • 1Econometric Institute Erasmus School of Economics Erasmus University Rotterdam P.O. Box 1738 3000 DR Rotterdam The Netherlands.

Production and Operations Management
|April 25, 2020
PubMed
Summary
This summary is machine-generated.

Vaccination prevents epidemics by creating herd immunity, protecting even unvaccinated individuals. This study reveals optimal vaccine allocation strategies for maximum population protection with limited resources.

Keywords:
disease modelingoptimizationresource allocationvaccination

More Related Videos

Author Spotlight: Optimizing CFU Determination for Efficient Assessment of TB Vaccine Efficacy and Antigen Presentation Analysis
06:26

Author Spotlight: Optimizing CFU Determination for Efficient Assessment of TB Vaccine Efficacy and Antigen Presentation Analysis

Published on: July 28, 2023

2.8K
Inverse Probability of Treatment Weighting Propensity Score using the Military Health System Data Repository and National Death Index
06:55

Inverse Probability of Treatment Weighting Propensity Score using the Military Health System Data Repository and National Death Index

Published on: January 8, 2020

15.0K

Related Experiment Videos

Last Updated: Dec 23, 2025

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies
08:34

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

Published on: February 6, 2019

20.9K
Author Spotlight: Optimizing CFU Determination for Efficient Assessment of TB Vaccine Efficacy and Antigen Presentation Analysis
06:26

Author Spotlight: Optimizing CFU Determination for Efficient Assessment of TB Vaccine Efficacy and Antigen Presentation Analysis

Published on: July 28, 2023

2.8K
Inverse Probability of Treatment Weighting Propensity Score using the Military Health System Data Repository and National Death Index
06:55

Inverse Probability of Treatment Weighting Propensity Score using the Military Health System Data Repository and National Death Index

Published on: January 8, 2020

15.0K

Area of Science:

  • Epidemiology
  • Mathematical Biology
  • Public Health

Background:

  • Vaccination is a key strategy for epidemic prevention.
  • Herd immunity protects unvaccinated individuals by reducing disease transmission.
  • Understanding the relationship between vaccination fraction and herd effect is crucial for effective public health policy.

Purpose of the Study:

  • To analytically investigate the relationship between the herd effect and vaccination fraction within the SIR model.
  • To identify optimal vaccination coverage levels for maximizing vaccine efficiency.
  • To provide insights for allocating limited vaccine stockpiles to multiple populations.

Main Methods:

  • Analytical study of the SIR compartmental model.
  • Mathematical analysis of the herd effect in relation to vaccination fraction.
  • Derivation of dose-optimal coverage for vaccine allocation.

Main Results:

  • The herd effect demonstrates a convex-concave relationship with the vaccination fraction.
  • Precise conditions for the emergence of the convex part of the herd effect were identified.
  • A unique dose-optimal coverage was determined for each population, maximizing efficiency per vaccine dose.

Conclusions:

  • Optimal vaccine allocation requires focusing on a subset of populations to achieve dose-optimal coverage.
  • Equal distribution of vaccines across all populations is less effective than targeted allocation.
  • Strategic vaccine deployment, guided by dose-optimal coverage, is crucial for maximizing public health impact with limited resources.