The 4 D's of Pellagra and Progress

Area of Science:

• Nutritional Science
• Demography
• Evolutionary Biology

Background:

• Nicotinamide homeostasis, central to the 'NAD world,' is crucial for societal transitions but is underappreciated.
• Human co-evolution with meat consumption and nicotinamide balance impacts health and demographics.

Purpose of the Study:

• To explore the role of nicotinamide homeostasis in demographic, epidemiological, and economic transitions.
• To analyze the impact of meat consumption and dietary balance on population health, aging, and fertility.

Main Methods:

• Review of co-evolutionary importance of meat and nicotinamide.
• Analysis of historical population data in relation to diet and fertility.
• Exploration of sustainable farming and 'Goldilocks' diet principles.

Main Results:

• Dietary imbalances (low or high meat) correlate with infectious diseases, shorter lifespans, or degenerative diseases and low fertility.
• A balanced 'Goldilocks' diet supports intellectual capital, health, and controlled population growth.
• Meat equity and sustainable farming are proposed for global progress.

Conclusions:

• Nicotinamide homeostasis is a key factor in population modernization and well-being.
• Dietary strategies, particularly meat equity and sustainable agriculture, are vital for future prosperity and biodiversity.
• Urgent implementation is needed to manage population quality and environmental health.