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Bioresponsive Nanomedicine: The Next Step of Deadliest Cancers' Theranostics
1Department of Thoracic Surgery, Shengjing Hospital, China Medical University, Shenyang, China.
Abstract:
Among all cancers, lung, breast, and prostate carcinoma are the three most fatal cancers. Although general therapeutic strategies and existent nanomedicine have been applied in relating cancer treatments, the side effects and potential damage induced by the off-target effect greatly lower the therapeutic efficiency. Recently, an increasing number of bioresponsive nanomaterials is recruited in fighting these deadliest cancers. Therefore, these latest bioresponsive nanomedicine are summarized in the current review. More specifically, the various novel nano-agents that could selectively respond to specific bio-conditions in malignant areas (e.g., pH, temperature, enzyme, Redox, elevated copper ion, etc.) are discussed in detail for their applications in cancer imaging (e.g., fluorescence, NIR, and MRI, etc.) and therapy (e.g., antiangiogenesis, chemotherapy, photothermal, and chemodynamic therapy, etc.). The development of next-generation of bioresponsive nanomedicine and challenges involved are further discussed for future design.
Insights
Bioresponsive nanomaterials offer targeted cancer therapy for lung, breast, and prostate carcinomas by responding to specific tumor conditions. This review details their use in advanced cancer imaging and treatment, minimizing side effects.
Area of Science:
- Oncology and Nanomedicine
- Biomaterials Science
Background:
- Lung, breast, and prostate carcinomas are leading causes of cancer mortality.
- Current nanomedicine faces limitations due to off-target effects, reducing therapeutic efficiency.
- Bioresponsive nanomaterials are emerging as a promising strategy to overcome these challenges.
Purpose of the Study:
- To review the latest advancements in bioresponsive nanomedicine for cancer treatment.
- To highlight nano-agents that selectively target malignant tumor microenvironments.
- To discuss applications in cancer imaging and therapy.
Main Methods:
- Literature review of bioresponsive nanomaterials.
- Analysis of nano-agents responding to specific tumor bio-conditions (pH, temperature, enzyme, Redox, copper ion).
- Examination of applications in fluorescence, NIR, MRI, antiangiogenesis, chemotherapy, photothermal, and chemodynamic therapy.
Main Results:
- Bioresponsive nanomaterials demonstrate selective targeting of cancer cells.
- These agents enable enhanced cancer imaging and diverse therapeutic modalities.
- Specific examples include nano-agents responding to pH, temperature, and enzyme levels.
Conclusions:
- Bioresponsive nanomedicine shows significant potential for improving cancer treatment efficacy and reducing side effects.
- Further development is needed for next-generation bioresponsive nanomedicine.
- Challenges in design and clinical translation require continued research.
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