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Updated: Dec 23, 2025

Standardized Data Acquisition for Neuromelanin-Sensitive Magnetic Resonance Imaging of the Substantia Nigra
Published on: September 8, 2021
Neuromelanin accumulation in Substantia nigra in vascular parkinsonism
Carlos Eduardo Mantese1, Tulio Becker Hainzenreder2
1Department of Neurology, Hospital Mãe de Deus, 2124, Rua Praia de Belas, Porto Alegre, RS, 90110-000, Brazil. mantese@gmail.com.
Abstract:
Vascular parkinsonism (VaP) is a term used to describe a parkinsonism of vascular cause. However, only ischemic or hemorrhagic lesions in the substantia nigra or nigrostriatal pathway, leading to a reduction of dopaminergic stimulus are pure VaP. Here, we report a case of true VaP due to nigrostriatal pathway stroke with accumulation of neuromelanin in Substantia nigra. This is the first description of neuromelanin accumulation from nigrostriatal damage. Also, it can help to understand the physiopathological changes in VaP.
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