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High affinity between CREBBP/p300 and NCOA evolved in vertebrates

Elin Karlsson1, Amanda Lindberg1, Eva Andersson1

  • 1Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden.

Protein Science : a Publication of the Protein Society
|April 25, 2020
PubMed
Summary

The high-affinity interaction between CREBBP/p300 and NCOA protein domains evolved in vertebrates, not all deuterostomes. This finding impacts understanding of transcriptional regulation evolution.

Keywords:
ACTRCBPCIDCREBBPNCBDechinodermintrinsically disordered proteinp300protein evolutionprotein-protein interaction

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