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Updated: Dec 23, 2025

Doppler Optical Coherence Tomography of Retinal Circulation
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[Progress of quantitative intravascular optical coherence tomography].

Fei Yang1, Zheng Sun1

  • 1Department of Electronic and Communication Engineering, North China Electric Power University, Baoding, Hebei 071003, P.R.China.

Sheng Wu Yi Xue Gong Cheng Xue Za Zhi = Journal of Biomedical Engineering = Shengwu Yixue Gongchengxue Zazhi
|April 25, 2020
PubMed
Summary

Quantitative intravascular optical coherence tomography (qIVOCT) enhances plaque characterization beyond standard IVOCT imaging. This review details methods for measuring optical, elastic, and hemodynamic parameters for improved tissue analysis.

Keywords:
Intravascular optical coherence tomographyelastic parameterhemodynamic parameteoptical parameterquantitative imaging

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Area of Science:

  • Biomedical Imaging
  • Cardiovascular Research
  • Medical Technology

Background:

  • Intravascular optical coherence tomography (IVOCT) offers high-resolution visualization of coronary arteries.
  • Standard IVOCT gray-scale images lack sufficient detail for accurate plaque tissue characterization (calcified, fibrous, lipidic, mixed).

Purpose of the Study:

  • To review the advancements in quantitative IVOCT (qIVOCT).
  • To introduce methods for quantitatively measuring optical, elastic, and hemodynamic parameters of vessel wall and plaque tissues.
  • To forecast potential future developments in qIVOCT.

Main Methods:

  • Review of current quantitative measurement techniques using IVOCT gray-scale images.
  • Analysis of methods utilizing raw backscattered signals for quantitative analysis.
  • Discussion of physiological contrast mechanisms in qIVOCT.

Main Results:

  • Quantitative analysis provides crucial physiological contrast mechanisms.
  • Characteristic tissue parameters with clinical diagnostic value can be obtained.
  • Current methods enable quantitative measurement of optical, elastic, and hemodynamic properties.

Conclusions:

  • qIVOCT is essential for detailed plaque tissue characterization.
  • Further development in qIVOCT methods promises enhanced diagnostic capabilities.
  • This review highlights the progress and future directions of qIVOCT.