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Associations between Exposure to Bisphenol A and Behavioral and Cognitive Function in Children with

Seung-Jin Yoo1, Hyunjoo Joo2, Dohyun Kim3

  • 1Environmental Health Center, Dankook University Medical Center.

Clinical Psychopharmacology and Neuroscience : the Official Scientific Journal of the Korean College of Neuropsychopharmacology
|April 25, 2020
PubMed

Insights

Bisphenol A (BPA) exposure is linked to negative behavioral and cognitive effects in children, particularly boys with ADHD. Further research is needed to understand these sex- and group-specific associations.

Area of Science:

  • Environmental Health
  • Neuroscience
  • Pediatrics

Background:

  • Bisphenol A (BPA) is a ubiquitous synthetic chemical found in plastics and resins.
  • Understanding BPA's impact on child development, especially in those with attention-deficit/hyperactivity disorder (ADHD), is crucial.

Purpose of the Study:

  • To investigate the association between BPA exposure and behavioral and cognitive function in children with ADHD and healthy controls.
  • To analyze sex- and group-specific differences in BPA's effects on behavior and cognition.

Main Methods:

  • Urinary BPA levels were measured in 444 children (6-10 years old), including 195 with ADHD and 249 controls.
  • Behavioral assessments included the Korean ADHD Rating Scale (K-ARS) and Behavior Assessment System for Children (BASC-2).
  • Cognitive function was evaluated using the Continuous Performance Test (ADHD Diagnostic System [ADS]).

Main Results:

  • Higher BPA levels correlated with poorer behavioral scores (hyperactivity, aggression, anxiety, depression) and cognitive function (visual/auditory errors, response time variability).
  • These associations were primarily observed in boys and the control group, not in children with ADHD or girls.
  • Subgroup analysis highlighted significant differences in behavior and cognition across BPA tertile groups, particularly in boys and controls.

Conclusions:

  • BPA exposure is associated with adverse behavioral and cognitive outcomes in children.
  • The study highlights potential sex- and group-specific differences in BPA's neurodevelopmental impact.
  • Further research is warranted to elucidate the underlying mechanisms driving these observed disparities.
Abstract

Keywords:
AttentionAttention deficit-hyperactivity disorderBisphenol AChild behaviorToxic environmental substances.

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