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Dynamic Monitoring of Seroconversion using a Multianalyte Immunobead Assay for Covid-19
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COVID-19 Serosurveillance May Facilitate Return-to-Work Decisions
Martin Krsak1, Steven C Johnson1, Eric M Poeschla1
1University of Colorado School of Medicine, Aurora, Colorado.
The American Journal of Tropical Medicine and Hygiene
|April 25, 2020
Summary
To safely reopen the economy during the COVID-19 pandemic, consider immune individuals for workforce reintroduction. Serosurveillance testing can determine transmissibility and aid "cleared for business" decisions.
Area of Science:
- Public Health
- Epidemiology
- Immunology
Background:
- The COVID-19 pandemic necessitates public health interventions alongside economic considerations.
- Early workforce reintroduction of immune individuals is crucial for economic stability.
- Current diagnostic methods like reverse transcriptase-polymerase chain reaction (RT-PCR) have limitations in determining immune status.
Purpose of the Study:
- To explore strategies for safe economic reopening during the COVID-19 pandemic.
- To evaluate the role of immune status in workforce reintroduction.
- To assess the utility of serosurveillance in conjunction with pathogen testing for decision-making.
Main Methods:
- Review of current public health strategies for COVID-19.
- Analysis of limitations of RT-PCR testing for immune status determination.
- Proposal for targeted serosurveillance as a supplementary diagnostic tool.
Main Results:
- RT-PCR testing shows sensitivity and timing concerns and does not confirm cleared infection.
- Immune individuals may be safely reintroduced to the workforce.
- Serosurveillance can identify individuals with cleared infections and potentially reduced transmissibility.
Conclusions:
- Targeted serosurveillance, potentially combined with direct pathogen testing, can inform "cleared for business" decisions.
- Immune status determination is key for balancing public health and economic recovery.
- A multi-faceted approach is needed to manage the pandemic's impact.
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