Non-AIDS defining cancers: a comprehensive update on diagnosis and management

Area of Science:

• Oncology
• Infectious Diseases
• Public Health

Background:

• Combined antiretroviral therapy (cART) has improved outcomes for people living with HIV (PLWH).
• However, there is an increasing incidence of non-AIDS defining cancers in PLWH on cART.
• These include lung, breast, colorectal, prostate cancers, hepatocellular carcinoma, and Hodgkin's lymphoma.

Purpose of the Study:

• To provide an updated review of non-AIDS defining cancers in PLWH.
• To discuss the diagnosis and management strategies for these cancers.
• To explore potential future scenarios in cancer care for PLWH.

Main Methods:

• Literature review of recent studies and clinical information.
• Synthesis of current data on cancer incidence, diagnosis, and treatment in PLWH.
• Analysis of trends and future projections.

Main Results:

• Non-AIDS defining cancers are a growing concern in the PLWH population.
• Early suspicion and diagnosis are critical for effective management.
• Management requires a multidisciplinary approach tailored to PLWH.

Conclusions:

• Infectious disease specialists must be vigilant in suspecting and diagnosing non-AIDS defining cancers in PLWH.
• Updated knowledge and tailored management strategies are essential.
• Future research should focus on prevention and improved treatment outcomes.