Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Obesity01:24

Obesity

1.1K
The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in...
1.1K
Psychoneuroimmunology: Diabetes and Cancer01:19

Psychoneuroimmunology: Diabetes and Cancer

361
Chronic stress has been linked to both the onset and progression of serious health conditions, including Type 2 diabetes and cancer. Type 2 diabetes, a widespread chronic illness, is closely associated with obesity and insulin resistance, both of which often worsen under stress. Studies indicate that men experiencing high levels of chronic stress face a 45% higher risk of developing diabetes compared to those with minimal stress. Stress triggers physiological responses that elevate blood...
361
Diabetes Mellitus: Type 2 and Gestational01:22

Diabetes Mellitus: Type 2 and Gestational

4.2K
Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
4.2K
Pathophysiology of Diabetes01:20

Pathophysiology of Diabetes

2.9K
Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
2.9K
Pharmacokinetics in Obese Patients: Drug Absorption and Distribution01:25

Pharmacokinetics in Obese Patients: Drug Absorption and Distribution

181
Obesity significantly alters the pharmacokinetic processes of drug absorption and distribution, presenting unique challenges in medical treatment. The increased fat tissue and decreased lean muscle in obese individuals can significantly affect how drugs are absorbed into the body and distributed across different tissues. This alteration can lead to variances in the effectiveness and safety of medications, necessitating adjustments in dosing or drug selection for obese patients.One notable...
181
Teeth01:15

Teeth

1.5K
The formation of teeth, also known as odontogenesis, is a complex process that begins in utero, around the sixth week of embryonic development. There are three stages to this process: the bud stage, the cap stage, and the bell stage.
In the bud stage, the tooth germ (an aggregation of cells) starts to form in the developing jawbone. During the cap stage, the tooth germ differentiates into enamel organ, dental papilla, and dental sac, which will later develop into the tooth's enamel, dentin...
1.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Salivary Biomarkers as Predictors of Obesity and Intermediate Hyperglycemia in Adolescents.

Frontiers in public health·2022
Same author

Saliva Exhibits High Sensitivity and Specificity for the Detection of SARS-COV-2.

Diseases (Basel, Switzerland)·2021
Same author

Longitudinal caries prevalence in a comprehensive, multicomponent, school-based prevention program.

Journal of the American Dental Association (1939)·2021
Same author

Short Sleep Duration and Screen-Based Activities: A Longitudinal Multilevel Analysis.

American journal of lifestyle medicine·2020
Same author

Annual alveolar bone loss in subjects with cardiovascular disease adjusting for associated systemic diseases and risk factors: a retrospective study.

BMC oral health·2020
Same author

Annual alveolar bone loss in older adults taking oral bisphosphonate: a retrospective cohort study.

BMC oral health·2019

Related Experiment Video

Updated: Dec 23, 2025

A Mouse Model for Pathogen-induced Chronic Inflammation at Local and Systemic Sites
09:52

A Mouse Model for Pathogen-induced Chronic Inflammation at Local and Systemic Sites

Published on: August 8, 2014

18.0K

Disease reciprocity between gingivitis and obesity.

J Max Goodson1

  • 1The Forsyth Institute, Cambridge, MA.

Journal of Periodontology
|April 25, 2020
PubMed
Summary

Obesity significantly worsens gingivitis in children. This interaction increases collagen breakdown, releasing hydroxyproline (Hyp) in saliva and plasma, suggesting a reciprocal relationship between these conditions.

Area of Science:

  • Oral health
  • Pediatric health
  • Metabolomics

Background:

  • Periodontal diseases are linked to systemic health issues.
  • Investigating the interplay between obesity and gingivitis in children is crucial.
  • Metabolomic analysis offers insights into disease mechanisms.

Purpose of the Study:

  • To explore the relationship between obesity and gingivitis in children.
  • To identify shared biochemical markers in saliva and plasma.
  • To understand the impact of co-occurring obesity and gingivitis.

Main Methods:

  • Collected saliva and plasma from 68 eleven-year-old children.
  • Assessed gingivitis severity and obesity via waist circumference.
  • Utilized untargeted metabolomic analysis to identify biochemical correlations.
Keywords:
collagengingivitishydroxyprolinemetabolomicsobesity

More Related Videos

Isolation, Characterization and Functional Examination of the Gingival Immune Cell Network
05:07

Isolation, Characterization and Functional Examination of the Gingival Immune Cell Network

Published on: February 16, 2016

11.3K
Isolation, Processing and Analysis of Murine Gingival Cells
09:47

Isolation, Processing and Analysis of Murine Gingival Cells

Published on: July 2, 2013

19.7K

Related Experiment Videos

Last Updated: Dec 23, 2025

A Mouse Model for Pathogen-induced Chronic Inflammation at Local and Systemic Sites
09:52

A Mouse Model for Pathogen-induced Chronic Inflammation at Local and Systemic Sites

Published on: August 8, 2014

18.0K
Isolation, Characterization and Functional Examination of the Gingival Immune Cell Network
05:07

Isolation, Characterization and Functional Examination of the Gingival Immune Cell Network

Published on: February 16, 2016

11.3K
Isolation, Processing and Analysis of Murine Gingival Cells
09:47

Isolation, Processing and Analysis of Murine Gingival Cells

Published on: July 2, 2013

19.7K
  • Analyzed data using t-tests and regression.

    • Main Results:

    • Obesity was associated with increased height and permanent teeth count.
    • Obesity significantly increased gingivitis severity; combined conditions showed highest redness.
    • Hydroxyproline (Hyp), a collagen breakdown product, was elevated in children with both obesity and gingivitis.

    Conclusions:

    • Obesity exacerbates gingivitis in children.
    • A potential disease reciprocity exists between obesity and gingivitis.
    • Shared activated neutrophils may drive collagen destruction and Hyp release.