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Updated: Dec 23, 2025

A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products
Published on: October 4, 2019
Psathyrins: Antibacterial Diterpenoids from Psathyrella candolleana
Ya-Pei Liu1, Quan Dai1, Wen-Xuan Wang1
1School of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan 430074, People's Republic of China.
Abstract:
Two skeletally novel tetracyclic diterpenoids, psathyrins A (1) and B (2), have been characterized from cultures of the basidiomycete Psathyrella candolleana. Their structures including absolute configurations were established by means of spectroscopic methods, as well as ECD calculations. They possess a novel 5/5/4/6-fuesd ring system, for which the biosynthetic pathway is proposed. Compounds 1 and 2 inhibited the growth of Staphylococcus aureus and Salmonella enterica.
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