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Updated: Dec 23, 2025

Assessment of the Metabolic Effects of Isocaloric 2:1 Intermittent Fasting in Mice
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Intermittent Fasting: A Heart Healthy Dietary Pattern?

Tiffany A Dong1, Pratik B Sandesara2, Devinder S Dhindsa2

  • 1Department of Medicine; Emory Clinical Cardiovascular Research Institute.

The American Journal of Medicine
|April 25, 2020
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Summary

Intermittent fasting may benefit heart health by improving weight, blood pressure, and diabetes control. Further research is needed to confirm these cardiovascular benefits.

Keywords:
Alternative day fastCircadianDiabetesDyslipidemiaHypertensionTime-restricted feeding

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Area of Science:

  • Cardiology
  • Nutritional Science
  • Metabolic Health

Background:

  • Dietary patterns like DASH and Mediterranean diets are known to improve cardiac health.
  • Intermittent fasting (IF) is a dietary pattern involving timed fasting periods, with regimens like alternative-day fasting and time-restricted eating.
  • While large trials are lacking, current human studies suggest IF may reduce cardiovascular disease risk.

Purpose of the Study:

  • To review the current literature on the potential cardiovascular benefits of intermittent fasting.
  • To explore the mechanisms through which intermittent fasting may impact cardiac health.
  • To propose future research directions in this field.

Main Methods:

  • Systematic review of existing human studies on intermittent fasting and cardiovascular outcomes.
  • Analysis of data related to weight control, hypertension, dyslipidemia, and diabetes.
  • Evaluation of proposed biological pathways, including oxidative stress, circadian rhythms, and ketogenesis.

Main Results:

  • Intermittent fasting shows potential for improving cardiovascular risk factors.
  • Observed benefits include improvements in weight management, hypertension, dyslipidemia, and diabetes control.
  • Potential mechanisms involve reduced oxidative stress, optimized circadian rhythms, and ketogenesis.

Conclusions:

  • Intermittent fasting may offer significant cardiovascular benefits.
  • Further large-scale, randomized controlled trials are necessary to establish causality and optimal IF protocols.
  • Research should focus on elucidating the precise mechanisms and long-term effects of IF on cardiovascular health.