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TMS activation site estimation using multiscale realistic head models
Jose Gomez-Tames1,2, Ilkka Laakso3, Takenobu Murakami4
1Department of Electrical and Mechanical Engineering, Nagoya Institute of Technology, Nagoya, Aichi 466-8555, Japan.
Journal of Neural Engineering
|April 25, 2020
Summary
This study presents a novel imaging technique using individualized head models to precisely locate Transcranial Magnetic Stimulation (TMS) activation sites. The method accurately identified the cortical activation site, offering a new tool for TMS research.
Area of Science:
- Neuroscience
- Biophysics
- Computational Modeling
Background:
- Transcranial Magnetic Stimulation (TMS) is a non-invasive brain stimulation technique.
- Accurately determining TMS cortical activation sites is crucial but remains controversial.
- Computational models offer a way to elucidate these activation sites.
Purpose of the Study:
- To present an imaging technique for estimating TMS activation cortical sites.
- To utilize individualized multi-scale realistic head models.
- To incorporate experimentally-derived TMS fields for precise localization.
Main Methods:
- Computed induced electric fields (EF) using subject-specific head models and TMS coil configurations.
- Applied suprathreshold stimulation for relaxed muscles.
- Calculated pyramidal tract model activation based on experimentally-derived EFs to determine cortical activation sites.
Main Results:
- Identified the TMS activation site at the anterior wall of the central sulcus.
- Results aligned with concurrent TMS/fMRI studies.
- Electric field strength showed some inconsistencies with TMS/fMRI findings.
Conclusions:
- Multiscale physical modeling is a feasible imaging technique for investigating TMS activation sites.
- Combining subject-specific modeling with experimental TMS measurements provides a viable TMS imaging technique under suprathreshold conditions.
