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Updated: Dec 23, 2025

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Specialized Pediatric Palliative Care in Neonates with Life-Limiting Illness: A Systematic Review

Gregorio Zuniga-Villanueva1, Kimberley Widger2,3, Christina Medeiros2

  • 1Department of Pediatrics, McMaster University, Hamilton, Ontario, Canada.

American Journal of Perinatology
|April 25, 2020
PubMed

Insights

Specialized pediatric palliative care (PPC) may benefit neonates with life-limiting conditions and their families. Further research with robust statistical analysis is needed to confirm the impact of PPC.

Area of Science:

  • Neonatal Medicine
  • Palliative Care Research
  • Quality of Life Studies

Background:

  • Life-limiting conditions in neonates present complex care challenges.
  • Standard care may not fully address the multifaceted needs of these infants and their families.
  • The role of specialized pediatric palliative care (PPC) requires further investigation.

Purpose of the Study:

  • To evaluate the impact of specialized pediatric palliative care (PPC) versus standard care for neonates with life-limiting conditions.
  • To synthesize existing evidence on PPC outcomes in this population.

Main Methods:

  • Comprehensive literature search across multiple databases (MEDLINE, PsycINFO, etc.) from January 2000 to September 2018.
  • Inclusion of randomized clinical trials, observational studies, and administrative database analyses.
  • Qualitative synthesis of data from eight selected studies due to heterogeneity precluding meta-analysis.

Main Results:

  • Eight studies met inclusion criteria, covering psychological, social, spiritual support, communication, care location, symptom management, bereavement, and parental outcomes.
  • A meta-analysis was not feasible due to outcome definition variability.
  • Qualitative synthesis provided insights into various aspects of care and family experience.

Conclusions:

  • Specialized pediatric palliative care (PPC) shows potential to impact neonates with life-limiting conditions and their families.
  • High-quality studies with rigorous statistical analysis are necessary to definitively establish the benefits of PPC.
  • Further research is warranted to guide optimal PPC implementation.
Abstract

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