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Multiple Sclerosis Treatment and Melanoma Development.

Maria Luigia Carbone1, Pedro Miguel Lacal2, Serena Messinese3

  • 1Laboratory of Experimental Immunology, IDI-IRCCS, 00167 Rome, Italy.

International Journal of Molecular Sciences
|April 26, 2020
PubMed
Summary
This summary is machine-generated.

Disease-modifying therapies for multiple sclerosis (MS), like natalizumab and fingolimod, may indirectly promote melanoma evolution by affecting the tumor microenvironment, not through direct action on cancer cells.

Keywords:
VEGF-Afingolimodmelanomanatalizumab

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Area of Science:

  • Oncology
  • Immunology
  • Dermatology

Background:

  • Disease-modifying therapies (DMTs) such as natalizumab and fingolimod are used for multiple sclerosis (MS).
  • These MS treatments have been linked to an increased risk of developing cutaneous melanoma.
  • Understanding the potential mechanisms behind this association is crucial for patient safety.

Observation:

  • A case study of a 48-year-old woman revealed melanoma and atypical nevi after sequential treatment with natalizumab and fingolimod.
  • Immunohistochemistry of the patient's melanoma biopsy showed T cell and leukocyte infiltration, along with vascular endothelial growth factor (VEGF)-A expression.
  • In vitro analysis of melanoma cell lines was performed to assess the effects of natalizumab and fingolimod.

Findings:

  • Both natalizumab and fingolimod inhibited melanoma cell proliferation in vitro.
  • The effect on melanoma cell migration varied, with promotion or blockage observed depending on the cell line.
  • VEGF-A secretion was increased in one cell line following fingolimod treatment.

Implications:

  • In vitro findings do not support a direct role for natalizumab or fingolimod in melanoma progression.
  • These MS therapies might indirectly influence melanoma evolution by modulating the tumor microenvironment.
  • Further research is needed to elucidate the complex interplay between MS DMTs and melanoma development.