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High-Density Lipoprotein Cholesterol in Age-Related Ocular Diseases

Bjorn Kaijun Betzler1, Tyler Hyungtaek Rim2,3, Charumathi Sabanayagam2,3

  • 1Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119228, Singapore.

Biomolecules
|April 26, 2020
PubMed

Insights

High-density lipoprotein cholesterol (HDL-C) roles in age-related eye diseases like AMD, cataract, glaucoma, and diabetic retinopathy are unclear. This review examines current epidemiological and genetic evidence on HDL-C

Area of Science:

  • Ophthalmology
  • Cardiovascular Science
  • Genetics

Background:

  • High-density lipoprotein cholesterol (HDL-C) is a common biomarker.
  • Its specific role in age-related ocular diseases is poorly understood.
  • Lipid profiles often include HDL-C measurements.

Purpose of the Study:

  • To review current knowledge on HDL-C's role in age-related eye diseases.
  • To summarize epidemiological and genetic evidence.
  • To investigate HDL-C's impact on AMD, cataract, glaucoma, and diabetic retinopathy.

Main Methods:

  • Literature review.
  • Analysis of epidemiological studies.
  • Examination of genetic evidence.

Main Results:

  • Current understanding of HDL-C's role in these diseases is limited.
  • Evidence linking HDL-C to pathogenesis and progression is being compiled.
  • Specific associations require further investigation.

Conclusions:

  • More research is needed to clarify HDL-C's function in age-related ocular diseases.
  • Understanding these links may inform future therapeutic strategies.
  • HDL-C's impact on AMD, cataract, glaucoma, and DR warrants further study.

Keywords:
age-related macular degenerationageingcataractdiabetic retinopathydyslipidaemiaglaucomahigh-density lipoproteinintraocular pressuremacular edemavisual impairment

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