Related Experiment Video For E-cadherin
Updated: Dec 23, 2025

Induction and Analysis of Epithelial to Mesenchymal Transition
Published on: August 27, 2013
E-Cadherin in Pancreatic Ductal Adenocarcinoma: A Multifaceted Actor during EMT
Michele Sommariva1, Nicoletta Gagliano1
1Department of Biomedical Sciences for Health, Università degli Studi di Milano, 20133 Milan, Italy.
Abstract:
Epithelial-to-mesenchymal transition (EMT) is a step-wise process observed in normal and tumor cells leading to a switch from epithelial to mesenchymal phenotype. In tumors, EMT provides cancer cells with a metastatic phenotype characterized by E-cadherin down-regulation, cytoskeleton reorganization, motile and invasive potential. E-cadherin down-regulation is known as a key event during EMT. However, E-cadherin expression can be influenced by the different experimental settings and environmental stimuli so that the paradigm of EMT based on the loss of E-cadherin determining tumor cell behavior and fate often becomes an open question. In this review, we aimed at focusing on some critical points in order to improve the knowledge of the dynamic role of epithelial cells plasticity in EMT and, specifically, address the role of E-cadherin as a marker for the EMT axis.
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Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...