Related Experiment Video
Updated: Dec 23, 2025
Measurements of Motor Function and Other Clinical Outcome Parameters in Ambulant Children with Duchenne Muscular Dystrophy
Published on: January 12, 2019
Correlation between benign joint hypermobility syndrome and primary focal hyperhidrosis in children: a novel concept
Vadood Javadi Parvaneh1,2, Hoda Shahvaladi1,2, Khosro Rahmani2
1Pediatric Pathology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Insights
Children with Benign Joint Hypermobility Syndrome (BJHS) have a significantly higher frequency of primary focal hyperhidrosis (PFH). This study highlights a notable association between BJHS and PFH in pediatric patients.
Area of Science:
- Pediatrics
- Dermatology
- Genetics
Background:
- Benign Joint Hypermobility Syndrome (BJHS) is a common hereditary connective tissue disorder in children.
- Autonomic nervous system involvement is frequently reported in BJHS patients.
Purpose of the Study:
- To investigate the prevalence of primary focal hyperhidrosis (PFH) in pediatric patients diagnosed with BJHS.
- To determine if a correlation exists between BJHS and PFH.
Main Methods:
- An observational-analytical, case-control study was conducted with children aged 3-15 years.
- BJHS was diagnosed using the Brighton criteria, followed by dermatological evaluation for hyperhidrosis.
- 130 children with BJHS were compared to 160 age- and sex-matched healthy controls.
Main Results:
- Primary focal hyperhidrosis (PFH) was diagnosed in 56.2% of children with BJHS, compared to 16.3% in controls.
- A statistically significant difference (P < 0.05) in PFH prevalence was observed between the BJHS group and the control group.
- No significant difference was found in the severity of hyperhidrosis between the two groups.
Conclusions:
- The study indicates a significant association between Benign Joint Hypermobility Syndrome and Primary Focal Hyperhidrosis in children.
- Further extensive research is recommended to validate these findings and elucidate the underlying mechanisms.
Background:
Benign joint hypermobility syndrome (BJHS) is one of the most common hereditary connective tissue disorders in children in which autonomic nervous system involvement has been reported. This study aimed to evaluate the frequency of primary focal hyperhidrosis in children with BJHS.
Methods:
This observational-analytical study was conducted in a case-control setting on children aged 3 to 15 years in 2018 at Mofid Children's Hospital, Tehran, Iran. Benign joint hypermobility syndrome was diagnosed according to the Brighton criteria; then, the patients referred to a dermatologist for evaluation of hyperhidrosis.
Results:
In total, 130 eligible patients with confirmed BJHS and 160 age- and sex-matched healthy subjects were enrolled in this study. Primary focal hyperhidrosis (PFH) was seen in 56.2 and 16.3% of the cases and controls, respectively, indicating a significant difference (P < 0.05). The severity of hyperhidrosis did not differ between the two groups.
Conclusion:
Although the results of the study showed a significant correlation between BJHS and PFH, more comprehensive studies are needed to confirm these findings.
More Related Videos
07:20Author Spotlight: Repetitive Transcranial Magnetic Stimulation Combined with Movement Observation in Cerebral Palsy
Published on: August 9, 2024
07:22Glycemic Impact on Knee Osteoarthritis Symptoms on Physical, Radiographic, and Inflammatory Markers among Individuals Aged 50 and Over with Diabetes
Published on: March 7, 2025
Related Concept Videos
01:20Accessory Structures of the Skin: Sweat Glands
Sweat glands are classified as merocrine glands; that is, the secretions are excreted by exocytosis through a duct without affecting the cells of the gland. There...
01:14Assessing Body Temperature - Axilla
Step 1: Perform hand hygiene and put on clean gloves to maintain infection control and prevent cross-contamination.
Step 2: Prepare the patient by explaining the procedure to ensure understanding and cooperation. Ensure privacy, expose the axilla, and inform the patient that minimal movement is crucial for an accurate reading.
Step 3: Adjust the patient’s clothing to expose only the axilla. It minimizes...
01:07Development of the Limb Synovial Joints
The mesenchymal stem cells differentiate into chondrocytes that form the hyaline cartilage, and later the cartilaginous model of the bone. This model further transforms into a bone. This process is known as endochondral ossification.
During development, the limbs...
01:30Assessment of Airway, Skin Color, and Use of Accessory Muscles
Introduction
The initial evaluation of a patient's respiratory system...
01:29Disorder of Water Balance
Dehydration
Dehydration occurs when the body loses fluids (particularly water).
Causes:
The major causes of dehydration include excessive sweating, fever, vomiting, diarrhea, and diuresis.
Signs and Symptoms:
Symptoms primarily include intense...
01:30Hypersensitivities
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...