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Updated: Dec 23, 2025

A Mouse Model to Assess Innate Immune Response to Staphylococcus aureus Infection
Published on: February 28, 2019
A Spectrum of Skin Disease: How Staphylococcus aureus Colonization, Barrier Dysfunction, and Cytokines Shape the Skin
Mary C Moran1, Lisa A Beck2, Christopher T Richardson2
1Department of Dermatology, University of Rochester Medical Center, Rochester, New York, USA; Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, New York, USA.
Abstract:
Cytokines are key mediators of skin homeostasis and disease through their effects on keratinocytes, skin barrier integrity, immune activation, and microbial ecology. Sirobhushanam et al. (2020) suggest that the IFN signature in lupus erythematosus (LE) alters expression of epithelial barrier and adhesin genes, which, in turn, promotes Staphylococcus aureus colonization. This work highlights the need to better understand both barrier function and S. aureus colonization in LE, two new potential therapeutic targets for the treatment of LE.
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